{"id":"W4400279651","doi":"10.1038/s41586-024-07642-3","title":"An anti-CRISPR that pulls apart a CRISPR–Cas complex","year":2024,"lang":"en","type":"article","venue":"Nature","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Beijing Municipal Science and Technology Commission; National Natural Science Foundation of China","keywords":"CRISPR; Computational biology; Steric effects; Chemistry; Function (biology); Biology; Biochemistry; Genetics; Stereochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006098156,0.0008282157,0.0006096616,0.0007943526,0.0007748762,0.001188541,0.00119043,0.001351222,0.005322959],"category_scores_gemma":[0.000551851,0.0007691126,0.0006643621,0.0003688176,0.0006815536,0.0005812224,0.0009283662,0.002233563,0.003394997],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006742647,"about_ca_system_score_gemma":0.0006599554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009384021,"about_ca_topic_score_gemma":0.001759644,"domain_scores_codex":[0.9989348,0.00006691912,0.00009302059,0.0003145472,0.0004811337,0.0001096106],"domain_scores_gemma":[0.9994583,0.0000873927,0.0001187067,0.000116139,0.00009171088,0.0001278145],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004193725,0.0000312573,0.0001412637,0.00004055633,0.00001304835,0.00007961442,0.00001070957,0.0000844336,0.9947279,0.0007824908,0.0005389034,0.00350782],"study_design_scores_gemma":[0.000009946514,0.00004292714,0.0004543804,0.000003877914,0.00001735065,0.0003342066,0.000007543391,0.001097699,0.9864017,0.0001307034,0.01148748,0.00001201732],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5523248,0.003380059,0.3589095,0.002685592,0.00340863,0.0006560741,0.002696726,0.009610196,0.06632841],"genre_scores_gemma":[0.8031028,0.001462681,0.1288743,0.002091813,0.0001889891,0.0002520544,0.002963977,0.001343696,0.0597196],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005322959,"threshold_uncertainty_score":0.01780707,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01094027364345788,"score_gpt":0.3448317198697604,"score_spread":0.3338914462263025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}