{"id":"W4400279651","doi":"10.1038/s41586-024-07642-3","title":"An anti-CRISPR that pulls apart a CRISPR–Cas complex","year":2024,"lang":"en","type":"article","venue":"Nature","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Beijing Municipal Science and Technology Commission; National Natural Science Foundation of China","keywords":"CRISPR; Computational biology; Steric effects; Chemistry; Function (biology); Biology; Biochemistry; Genetics; Stereochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001033742,0.0001824291,0.0001322186,0.00005450549,0.00005301545,0.00009123375,0.0002182332,0.0007942302,0.00008506372],"category_scores_gemma":[0.00001935121,0.0001655161,0.0001026834,0.0001142221,0.00003095578,0.000005363269,0.00005824395,0.0006908595,0.00003449059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001019224,"about_ca_system_score_gemma":0.00003407873,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007063445,"about_ca_topic_score_gemma":0.00001944538,"domain_scores_codex":[0.9990335,0.00002123635,0.0001094297,0.0004145401,0.0001516465,0.0002696868],"domain_scores_gemma":[0.9994395,0.000008049738,0.00001396775,0.0003937997,0.00003902248,0.0001056996],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000132086,0.00003515116,0.0007190543,0.00007526073,0.00006301519,0.00003640211,0.00008512576,0.0002603084,0.9327438,0.0002681858,0.06252737,0.003173101],"study_design_scores_gemma":[0.0001503666,0.0001017456,0.006547708,0.00002420472,0.00002616189,0.00006527935,0.00005690581,0.001288696,0.4936168,0.00005744523,0.4978167,0.0002480072],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9145167,0.04190725,0.0325618,0.001769211,0.002556576,0.0004323163,0.0001783236,0.0002929792,0.005784766],"genre_scores_gemma":[0.9963478,0.0002700012,0.0009191905,0.0009333676,0.0006798233,0.00000913271,0.0002740288,0.00004143165,0.0005251876],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4391271,"threshold_uncertainty_score":0.6749551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01094027364345788,"score_gpt":0.3448317198697604,"score_spread":0.3338914462263025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}