{"id":"W4400285269","doi":"10.1002/alz.14072","title":"Neurovascular coupling, functional connectivity, and cerebrovascular endothelial extracellular vesicles as biomarkers of mild cognitive impairment","year":2024,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Neurological Disorders and Stroke; American Heart Association; National Institute of General Medical Sciences; National Cancer Institute; National Institute on Aging; National Institute of Child Health and Human Development; U.S. Department of Veterans Affairs","keywords":"Extracellular vesicles; Neurovascular bundle; Extracellular; Cognitive impairment; Medicine; Neuroscience; Vesicle; Functional connectivity; Cardiology; Cognition; Chemistry; Psychology; Biology; Cell biology; Pathology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004824897,0.0004498889,0.0003331326,0.000836317,0.0002546624,0.0006270602,0.0002248205,0.000368842,0.001010099],"category_scores_gemma":[0.001153085,0.00009248954,0.0002224753,0.0003747122,0.0002046507,0.0003015084,0.000295243,0.0002598495,0.00009201837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002423548,"about_ca_system_score_gemma":0.0001923665,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002999334,"about_ca_topic_score_gemma":0.003340623,"domain_scores_codex":[0.9998833,0.0000309134,0.00001102388,0.00003177244,0.0000268494,0.00001619117],"domain_scores_gemma":[0.9996756,0.00006584693,0.0001454283,0.00001350816,0.0000548275,0.00004476815],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002487226,0.0002595276,0.9051077,0.0004932216,0.000817555,0.0005306621,0.0004027213,0.001559129,0.01378973,0.0005362224,0.001021545,0.07299484],"study_design_scores_gemma":[0.00001467525,0.0002969737,0.9939429,0.00004197691,0.0001372179,0.0005440434,0.0001392711,0.002370394,0.001160209,0.0008495199,0.0004869681,0.00001587676],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929305,0.004272164,0.0009730296,0.0001178086,0.00001872745,0.00002488173,0.000484558,0.00002804174,0.001150256],"genre_scores_gemma":[0.998609,0.000444896,0.0005498638,0.00001732185,0.00001378082,0.00001540148,0.0001610378,0.000001399843,0.0001872104],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002999334,"threshold_uncertainty_score":0.005963743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01482808555669649,"score_gpt":0.2504533491415116,"score_spread":0.2356252635848151,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}