{"id":"W4400285269","doi":"10.1002/alz.14072","title":"Neurovascular coupling, functional connectivity, and cerebrovascular endothelial extracellular vesicles as biomarkers of mild cognitive impairment","year":2024,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Neurological Disorders and Stroke; American Heart Association; National Institute of General Medical Sciences; National Cancer Institute; National Institute on Aging; National Institute of Child Health and Human Development; U.S. Department of Veterans Affairs","keywords":"Extracellular vesicles; Neurovascular bundle; Extracellular; Cognitive impairment; Medicine; Neuroscience; Vesicle; Functional connectivity; Cardiology; Cognition; Chemistry; Psychology; Biology; Cell biology; Pathology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004437778,0.0003149615,0.0002304795,0.0001089999,0.0001148699,0.00007419586,0.0001670456,0.0001536629,0.0002032414],"category_scores_gemma":[0.00005220953,0.0003280317,0.0003330662,0.0001422202,0.0003167521,0.00002076275,0.0002402537,0.0001298905,0.00004096085],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004748469,"about_ca_system_score_gemma":0.0001430545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005739744,"about_ca_topic_score_gemma":0.000007698939,"domain_scores_codex":[0.9980492,0.0001004023,0.0003725975,0.0007644117,0.0003695013,0.0003438806],"domain_scores_gemma":[0.9991713,0.00005943528,0.00009574719,0.0003903051,0.0001082478,0.0001749736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003177302,0.0004466881,0.01053359,0.0001078981,0.03212837,0.00005740333,0.00009866512,0.0001345349,0.947226,0.0007781997,0.00155578,0.006615076],"study_design_scores_gemma":[0.001673584,0.0005097578,0.01396801,0.00009649692,0.01157793,0.00007435062,0.0001597492,0.001561446,0.9611256,0.0003558615,0.008362905,0.0005343655],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7466277,0.2497864,0.002548927,0.00005756064,0.0003359127,0.0004101234,0.00006564714,0.00003846414,0.000129287],"genre_scores_gemma":[0.9981297,0.0007564438,0.0004520047,0.00008536209,0.000215343,0.00005556406,0.0002071319,0.00007063577,0.00002776648],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2515021,"threshold_uncertainty_score":0.9999171,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01482808555669649,"score_gpt":0.2504533491415116,"score_spread":0.2356252635848151,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}