{"id":"W4400293488","doi":"10.1002/alz.13880","title":"Extended genome‐wide association study employing the African genome resources panel identifies novel susceptibility loci for Alzheimer's disease in individuals of African ancestry","year":2024,"lang":"en","type":"review","venue":"Alzheimer s & Dementia","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Research Resources; National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Institute of Biomedical Imaging and Bioengineering; National Human Genome Research Institute; School of Medicine, University of California, San Francisco; National Institute of Mental Health; National Institute on Aging; University of California, Irvine; University of California, Davis; GE Healthcare; National Institute on Minority Health and Health Disparities; Genentech; H. Lundbeck A/S; Fujirebio Europe; North Bristol NHS Trust; Stichting MS Research; Newcastle University; Higher Education Funding Council for England; University of Arizona; National Association for Colitis and Crohn's Disease; U.S. Department of Defense; BRACE; University of Alabama at Birmingham; Novartis Pharmaceuticals Corporation; Takeda Pharmaceutical Company; University of Pittsburgh; University of California, San Diego; Johns Hopkins University; University of California, Los Angeles; Pfizer; University of Washington; Medical Research Council; Servier; Boston University; Rush University; F. Hoffmann-La Roche; Emory University; U.S. Department of Veterans Affairs; University of Pennsylvania; Columbia University; Massachusetts General Hospital; Translational Genomics Research Institute; Indiana University; Vanderbilt University; Wellcome Trust; Eisai; University of Southern California; Duke University; Office of Research and Development; Oregon Health and Science University; University of Michigan; University of California, San Francisco; Mayo Clinic; Merck; National Institutes of Health; Alzheimer's Drug Discovery Foundation; York University; BioClinica; Northwestern University; Biogen; University of Miami; Alzheimer's Research Trust; Hersenstichting; BrightFocus Foundation; Eli Lilly and Company; Bristol-Myers Squibb; Alzheimer's Association; School of Medicine, Boston University; AbbVie; Illinois Department of Public Health; University of Kentucky; New York University; Howard Hughes Medical Institute","keywords":"Genome-wide association study; Genome; Disease; Genetics; Biology; Genetic association; Gene; Single-nucleotide polymorphism; Medicine; Genotype; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002121428,0.0004825932,0.0007040815,0.00151319,0.000936331,0.0007600199,0.0004661935,0.0003940094,0.003126577],"category_scores_gemma":[0.002890077,0.0002244335,0.001112444,0.003712475,0.0002986729,0.000354616,0.0008536588,0.0006442883,0.0001729204],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002611022,"about_ca_system_score_gemma":0.0005021223,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008825559,"about_ca_topic_score_gemma":0.0133515,"domain_scores_codex":[0.9991388,0.0003091961,0.00006718604,0.0002709496,0.0001076956,0.0001061932],"domain_scores_gemma":[0.9988618,0.0004056918,0.0002863188,0.0001972318,0.0001387676,0.0001102379],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001389489,0.00006083339,0.9609498,0.0002855992,0.005084541,0.000735125,0.0003478607,0.0005306648,0.01023091,0.00050265,0.001751776,0.01813064],"study_design_scores_gemma":[0.00009619728,0.00008057585,0.9920324,0.00007654989,0.002275853,0.0005868766,0.0001361935,0.0006970024,0.0009038248,0.0004629332,0.002635611,0.00001585401],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9862074,0.003893729,0.00242338,0.0004130464,0.00003980231,0.00003704836,0.005893814,0.0000392086,0.001052591],"genre_scores_gemma":[0.9935347,0.0009856373,0.002178848,0.0001105353,0.00002912999,0.00004809218,0.002859587,0.00001416939,0.0002393253],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.008825559,"threshold_uncertainty_score":0.01754838,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08844431325443505,"score_gpt":0.3462737108407105,"score_spread":0.2578293975862754,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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