{"id":"W4400294177","doi":"10.1021/acs.jmedchem.4c00513","title":"Small Molecule Targeting PPM1A Activates Autophagy for <i>Mycobacterium tuberculosis</i> Host-Directed Therapy","year":2024,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; University of British Columbia","funders":"Shanghai Institute of Materia Medica, Chinese Academy of Sciences; Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China; National Sanitarium Association; Program of Shanghai Academic Research Leader; Canadian Institutes of Health Research; University of Ottawa","keywords":"Chemistry; Autophagy; Mycobacterium tuberculosis; Tuberculosis; Host (biology); Small molecule; Biochemistry; Apoptosis; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001181244,0.0002116023,0.0002263638,0.0001157175,0.000104218,0.0001617289,0.0001560006,0.0002604451,0.001027282],"category_scores_gemma":[0.00006192707,0.00008777059,0.0002196979,0.00008774983,0.0001786053,0.0001400665,0.0001858745,0.0004320213,0.0003222383],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000212515,"about_ca_system_score_gemma":0.0001425945,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001819146,"about_ca_topic_score_gemma":0.0003773178,"domain_scores_codex":[0.9999382,0.00001114284,0.000003889305,0.00001189688,0.00001635895,0.00001847041],"domain_scores_gemma":[0.9999731,0.000003461981,0.000009542968,0.000002508124,0.000003829002,0.000007604552],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001192948,0.00004264944,0.00007979378,0.00009888593,0.000005323891,0.00003710763,0.000008920331,0.0001601119,0.9955513,0.0001433439,0.0001796662,0.003573648],"study_design_scores_gemma":[0.00004766451,0.000611253,0.0007146649,0.000009641667,0.00001220326,0.0002283412,0.000007846578,0.0007213129,0.992732,0.00004288912,0.004866579,0.0000056388],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9661411,0.01061947,0.01377525,0.000463799,0.0001553975,0.0002026667,0.0005390947,0.0003876975,0.007715584],"genre_scores_gemma":[0.9905794,0.002595398,0.004679643,0.0001641014,0.00002046649,0.00004980916,0.0001711143,0.00001321061,0.001726853],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001027282,"threshold_uncertainty_score":0.003436625,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02794905921611393,"score_gpt":0.3179206033673014,"score_spread":0.2899715441511874,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}