{"id":"W4400306738","doi":"10.1186/s13063-024-08268-6","title":"Engaging Mood Brain Circuits with Psilocybin (EMBRACE): a study protocol for a randomized, placebo-controlled and delayed-start, neuroimaging trial in depression","year":2024,"lang":"en","type":"article","venue":"Trials","topic":"Psychedelics and Drug Studies","field":"Psychology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; Health Sciences Centre; Sunnybrook Health Science Centre; Toronto Rehabilitation Institute; University Health Network; University of Toronto; Centre for Addiction and Mental Health","funders":"Canadian Institutes of Health Research; Sunnybrook Foundation","keywords":"Psilocybin; Mood; Medicine; Major depressive disorder; Placebo; Neuroimaging; Depression (economics); Psychiatry; Antidepressant; Randomized controlled trial; Neuroplasticity; Clinical psychology; Functional neuroimaging; Psychology; Hallucinogen; Internal medicine; Anxiety","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007514773,0.004522515,0.005900613,0.001295479,0.001986244,0.001862632,0.002567072,0.005176804,0.02992406],"category_scores_gemma":[0.005687789,0.002006298,0.00226461,0.001217604,0.002227462,0.002004054,0.001329603,0.004662608,0.006126789],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0017623,"about_ca_system_score_gemma":0.005679977,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001391426,"about_ca_topic_score_gemma":0.003904567,"domain_scores_codex":[0.9962907,0.001713105,0.0003010388,0.0005932893,0.0004061223,0.0006957952],"domain_scores_gemma":[0.9971688,0.000566472,0.0006143862,0.0003541847,0.0003958106,0.0009003854],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.965462,0.0178242,0.0002400518,0.001315189,0.0003595383,0.00008476616,0.00009117684,0.000435319,0.00256765,0.0005204021,0.002399575,0.008700057],"study_design_scores_gemma":[0.9533256,0.04143448,0.0007027565,0.0001197499,0.0001828189,0.00001701837,0.00002054782,0.0003903598,0.0002780606,0.0004614381,0.003041585,0.00002555964],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.04521701,0.0008924133,0.002466598,0.0006541787,0.0008000495,0.9457383,0.001696712,0.0002776754,0.002257074],"genre_scores_gemma":[0.03093938,0.0005288637,0.003558522,0.0005983814,0.0002107198,0.9616274,0.0003050411,0.00001574915,0.00221595],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.02992406,"threshold_uncertainty_score":0.1001059,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1150840873569962,"score_gpt":0.4540869324500561,"score_spread":0.3390028450930599,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}