{"id":"W4400309698","doi":"10.1016/j.matbio.2024.06.007","title":"Interleukin-1α inhibits transforming growth factor-β1 and β2-induced extracellular matrix production, remodeling and signaling in human lung fibroblasts: Master regulator in lung mucosal repair","year":2024,"lang":"en","type":"article","venue":"Matrix Biology","topic":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Okanagan University College; St. Paul's Hospital; McMaster University; University of British Columbia; St. Joseph’s Healthcare Hamilton; University of British Columbia, Okanagan Campus","funders":"Canadian Institutes of Health Research; Social Sciences and Humanities Research Council of Canada; Mitacs","keywords":"Extracellular matrix; Transforming growth factor; Cell biology; Fibroblast; Pulmonary fibrosis; Signal transduction; Fibrosis; Transforming growth factor beta; Lung; Cancer research; Biology; Immunology; Chemistry; Medicine; Pathology; Internal medicine; Cell culture","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004600487,0.0003233888,0.0005197778,0.0005982137,0.00009442854,0.00005485893,0.00007293145,0.0003094939,0.000043417],"category_scores_gemma":[0.00006472332,0.0002912491,0.0001389688,0.0003086083,0.0001048453,0.0002746735,0.00007776354,0.0005017242,0.000002836209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002301721,"about_ca_system_score_gemma":0.0000887902,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002409049,"about_ca_topic_score_gemma":0.00004983032,"domain_scores_codex":[0.9977155,0.0001277955,0.0007423674,0.0008120203,0.0001292139,0.0004731351],"domain_scores_gemma":[0.9994611,0.00006229681,0.00006955866,0.0001992265,0.00006390279,0.0001439682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001004512,0.00007493055,0.01649999,0.003006278,0.00006454691,0.0002376516,0.001850999,0.00001996827,0.9744288,0.001864165,0.00005646053,0.0008916768],"study_design_scores_gemma":[0.01947764,0.01789111,0.03721892,0.06617298,0.002515333,0.007745401,0.01168555,0.4317633,0.3794372,0.0125763,0.005652277,0.007863997],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9819565,0.01560966,0.0003562605,0.0007903674,0.0003435537,0.0006989426,0.00002532298,0.0001716313,0.00004776013],"genre_scores_gemma":[0.998457,0.0001593116,0.0004496312,0.00002990452,0.000404121,0.00003077737,0.00005495545,0.00005466747,0.0003596144],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5949916,"threshold_uncertainty_score":0.999954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01469818618588776,"score_gpt":0.2891616134195927,"score_spread":0.274463427233705,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}