{"id":"W4400314143","doi":"10.1126/science.adi0908","title":"Evolution and host-specific adaptation of<i>Pseudomonas aeruginosa</i>","year":2024,"lang":"en","type":"article","venue":"Science","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":105,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Cambridge Institute for Medical Research, University of Cambridge; Samsung Biomedical Research Institute; Home Office; British Society for Antimicrobial Chemotherapy; Cystic Fibrosis Trust; Cystic Fibrosis Canada; Université de Montpellier; Wellcome Trust; Fondazione per la Ricerca sulla Fibrosi Cistica; Genome Canada; National Institute for Health and Care Research; Horizon 2020 Framework Programme; National Centre for the Replacement Refinement and Reduction of Animals in Research; NIHR Cambridge Biomedical Research Centre; Fondation Botnar; European Commission","keywords":"Pseudomonas aeruginosa; Adaptation (eye); Host (biology); Pathogen; Biology; Opportunistic pathogen; Human pathogen; Microbiology; Evolutionary biology; Bacteria; Genetics; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003069944,0.0001266028,0.0001192246,0.0002951779,0.0002616507,0.0004789209,0.0002031938,0.000469907,0.0004942961],"category_scores_gemma":[0.0005760959,0.0001066894,0.0001087138,0.0002389669,0.0002879688,0.0003980889,0.0005080592,0.0003077161,0.0001779902],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003465214,"about_ca_system_score_gemma":0.0002172482,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007886551,"about_ca_topic_score_gemma":0.001144966,"domain_scores_codex":[0.9998422,0.00004203448,0.000007467173,0.00004151657,0.00002637766,0.00004042282],"domain_scores_gemma":[0.9998186,0.00003618023,0.00006353112,0.0000241367,0.00002993997,0.0000276166],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001487335,0.00007348739,0.08451595,0.00008441586,0.00004266949,0.000478749,0.000616247,0.001487986,0.8783875,0.002753766,0.0003254352,0.03108523],"study_design_scores_gemma":[0.00001220825,0.0005756742,0.894382,0.00003827991,0.00006017155,0.003310381,0.001315971,0.009798728,0.07612682,0.002726942,0.01159491,0.00005800255],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969664,0.0005301601,0.0007950695,0.0001129245,0.000003920531,0.00000334006,0.00003614162,0.00001243879,0.001539564],"genre_scores_gemma":[0.9987106,0.0003300637,0.0004874254,0.00004525827,0.0000038287,0.000003066365,0.00005337444,0.000005774161,0.0003605764],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007886551,"threshold_uncertainty_score":0.002514243,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01151194528886777,"score_gpt":0.2330305452106284,"score_spread":0.2215185999217606,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}