{"id":"W4400314143","doi":"10.1126/science.adi0908","title":"Evolution and host-specific adaptation of<i>Pseudomonas aeruginosa</i>","year":2024,"lang":"en","type":"article","venue":"Science","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":105,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Cambridge Institute for Medical Research, University of Cambridge; Samsung Biomedical Research Institute; Home Office; British Society for Antimicrobial Chemotherapy; Cystic Fibrosis Trust; Cystic Fibrosis Canada; Université de Montpellier; Wellcome Trust; Fondazione per la Ricerca sulla Fibrosi Cistica; Genome Canada; National Institute for Health and Care Research; Horizon 2020 Framework Programme; National Centre for the Replacement Refinement and Reduction of Animals in Research; NIHR Cambridge Biomedical Research Centre; Fondation Botnar; European Commission","keywords":"Pseudomonas aeruginosa; Adaptation (eye); Host (biology); Pathogen; Biology; Opportunistic pathogen; Human pathogen; Microbiology; Evolutionary biology; Bacteria; Genetics; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001855625,0.00004637643,0.0000401138,0.0000336697,0.0000629727,0.00004429031,0.00005800228,0.00003217797,0.00000264823],"category_scores_gemma":[0.00001799522,0.00004078077,0.00001683466,0.0001794549,0.0002713402,0.00000988766,0.00004553363,0.00002469202,0.000003808178],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007997411,"about_ca_system_score_gemma":0.00007844785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001286209,"about_ca_topic_score_gemma":0.000005625379,"domain_scores_codex":[0.9995038,0.000008277376,0.00007403113,0.0002175044,0.00009002598,0.0001063632],"domain_scores_gemma":[0.9998007,0.000004097427,0.00001725987,0.0000999661,0.00004492177,0.00003307646],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000006409502,0.000003117868,0.0001448081,0.000006631447,0.000001191375,6.068491e-7,0.00004326074,0.000004312106,0.9917851,0.001338375,0.00005594954,0.006610224],"study_design_scores_gemma":[0.00007249587,0.0001079877,0.01062845,0.00002833843,0.000003690904,0.0000223186,0.0001123654,0.0008290854,0.9619913,0.00005252931,0.02606062,0.00009082775],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943303,0.003661484,0.001116498,0.00007726663,0.0003802571,0.00004450332,0.00000551505,0.000008609029,0.0003756056],"genre_scores_gemma":[0.9983115,0.000225761,0.001277133,0.00001578156,0.00009828372,6.922916e-7,0.000003720951,0.000003425217,0.00006373067],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02979382,"threshold_uncertainty_score":0.1662992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01151194528886777,"score_gpt":0.2330305452106284,"score_spread":0.2215185999217606,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}