{"id":"W4400316580","doi":"10.1016/j.jbc.2024.107538","title":"Residues in the fructose-binding pocket are required for ketohexokinase-A activity","year":2024,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Diet, Metabolism, and Disease","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"York University; New York University Abu Dhabi","keywords":"Fructose; Genetics; Biology; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009355605,0.0002014697,0.0002423724,0.00006357618,0.0002292187,0.0003900078,0.0002708528,0.0002377678,0.001062638],"category_scores_gemma":[0.0002259771,0.0001272377,0.000200044,0.0001121217,0.0001928658,0.0003009226,0.0001911643,0.0003591026,0.0002585723],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002446089,"about_ca_system_score_gemma":0.0003687488,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001035169,"about_ca_topic_score_gemma":0.001116733,"domain_scores_codex":[0.9999344,0.000009435167,0.000006352451,0.00001597027,0.00002001244,0.0000138368],"domain_scores_gemma":[0.9999288,0.00001838679,0.00002052929,0.000004080282,0.000008343779,0.0000198114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001305049,0.0002866215,0.01836766,0.0004224176,0.0001003274,0.001881006,0.0002206247,0.005160098,0.9494636,0.003663345,0.001712958,0.01741633],"study_design_scores_gemma":[0.000609141,0.0006376754,0.1057805,0.00009974145,0.0001752607,0.004540104,0.0009533672,0.06409736,0.7961182,0.005323932,0.02151006,0.0001546859],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966292,0.0006878255,0.001590902,0.0001002658,0.00002871688,0.000005988419,0.0001113751,0.00004876085,0.0007969942],"genre_scores_gemma":[0.9977482,0.000315597,0.001312492,0.00004762058,0.000004707778,0.000004350522,0.0002458308,0.00001063809,0.0003104185],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001062638,"threshold_uncertainty_score":0.003554881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06367224857463773,"score_gpt":0.3321801252846991,"score_spread":0.2685078767100614,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}