{"id":"W4400318308","doi":"10.3390/antibiotics13070624","title":"Mutations in embB406 Are Associated with Low-Level Ethambutol Resistance in Canadian Mycobacterium tuberculosis Isolates","year":2024,"lang":"en","type":"article","venue":"Antibiotics","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Public Health Agency of Canada","funders":"Public Health Agency of Canada","keywords":"Ethambutol; Mycobacterium tuberculosis; Drug resistance; Biology; Genetics; Tuberculosis; Mutation; Microbiology; Medicine; Gene; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005237423,0.0001804756,0.0004113416,0.0006042023,0.00005562329,0.00004478356,0.00009075252,0.0002456085,0.00006336863],"category_scores_gemma":[0.001312589,0.0001525032,0.00006122787,0.001082095,0.0001141342,0.0001127715,0.00002121049,0.0006093926,0.00008022992],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006011227,"about_ca_system_score_gemma":0.0007188202,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.07399879,"about_ca_topic_score_gemma":0.8944964,"domain_scores_codex":[0.9981442,0.0001474828,0.0003569493,0.0003744645,0.0001635598,0.0008133413],"domain_scores_gemma":[0.9988673,0.0004003574,0.00003914772,0.0002394252,0.0001107507,0.0003430338],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00007131047,0.0001328716,0.9901282,0.0003249212,0.0001543378,0.001584005,0.0005687231,0.00005577991,0.001552513,0.0005149179,0.004680258,0.0002321394],"study_design_scores_gemma":[0.0005311326,0.00009848126,0.9911317,0.001959605,0.00004398356,0.00002174025,0.0002226564,0.003501165,0.0005576322,0.0001949146,0.001546592,0.0001904105],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9806463,0.0009128716,0.000011159,0.0150076,0.0001163869,0.0003166109,0.0001980006,0.00005717393,0.002733935],"genre_scores_gemma":[0.9972636,0.0003119688,0.0002820639,0.0009412779,0.00005255549,0.000002331056,0.0002246736,0.00003722045,0.0008843577],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8204976,"threshold_uncertainty_score":0.9321675,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.024221195882857,"score_gpt":0.3034239104725293,"score_spread":0.2792027145896723,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}