{"id":"W4400318308","doi":"10.3390/antibiotics13070624","title":"Mutations in embB406 Are Associated with Low-Level Ethambutol Resistance in Canadian Mycobacterium tuberculosis Isolates","year":2024,"lang":"en","type":"article","venue":"Antibiotics","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Public Health Agency of Canada","funders":"Public Health Agency of Canada","keywords":"Ethambutol; Mycobacterium tuberculosis; Drug resistance; Biology; Genetics; Tuberculosis; Mutation; Microbiology; Medicine; Gene; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003017635,0.0004507431,0.0003406452,0.001620603,0.001271336,0.0005892009,0.0005217661,0.0004334098,0.002205326],"category_scores_gemma":[0.001611128,0.0003248899,0.0003479102,0.002074829,0.0005672508,0.000141822,0.0004238134,0.0004225516,0.000224247],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004188182,"about_ca_system_score_gemma":0.004579697,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.8505054,"about_ca_topic_score_gemma":0.9038169,"domain_scores_codex":[0.9995221,0.00002618772,0.00002794365,0.00007709298,0.0002350397,0.0001116048],"domain_scores_gemma":[0.9993119,0.00006391814,0.0001881188,0.00002997629,0.0003019972,0.0001041378],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009637157,0.00009070283,0.8823138,0.0003147029,0.0001461983,0.003613798,0.001868315,0.0007695717,0.07431191,0.0003574897,0.001921625,0.03332807],"study_design_scores_gemma":[0.00001361112,0.00005003657,0.9898582,0.00003252143,0.00006988699,0.002128225,0.0005991818,0.0004951976,0.004049821,0.00004673217,0.0026335,0.00002305532],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958325,0.0005748764,0.0001938432,0.000149494,0.000005190768,0.00001210258,0.001218125,0.00002166433,0.001992288],"genre_scores_gemma":[0.9978667,0.0003166668,0.000451104,0.00004648146,0.000002932375,0.000003647006,0.0007214189,0.000009099286,0.0005819474],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1494946,"threshold_uncertainty_score":0.30075,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.024221195882857,"score_gpt":0.3034239104725293,"score_spread":0.2792027145896723,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}