{"id":"W4400323905","doi":"10.3390/v16071076","title":"Downregulation of miRNA-26a by HIV-1 Enhances CD59 Expression and Packaging, Impacting Virus Susceptibility to Antibody-Dependent Complement-Mediated Lysis","year":2024,"lang":"en","type":"article","venue":"Viruses","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Université de Montréal; Montreal Clinical Research Institute","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"Downregulation and upregulation; CD59; microRNA; Complement (music); Lysis; Human immunodeficiency virus (HIV); Virus; Antibody; Virology; Immunology; Biology; Cancer research; Complement system; Chemistry; Genetics; Gene; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000160227,0.000251851,0.0002825134,0.0001619885,0.0001790211,0.0005446987,0.0001551219,0.0002897384,0.001515986],"category_scores_gemma":[0.0002416573,0.0001645582,0.0002866419,0.00009048275,0.0001893738,0.0001593679,0.0002069946,0.0005423884,0.0005349495],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002792607,"about_ca_system_score_gemma":0.0002315471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004743139,"about_ca_topic_score_gemma":0.0005255911,"domain_scores_codex":[0.9998385,0.00001866693,0.00001905584,0.00004481099,0.00004515655,0.00003373571],"domain_scores_gemma":[0.9999135,0.00001850966,0.00002424875,0.00001122893,0.00001301173,0.00001964184],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007256784,0.00001247131,0.0001717492,0.00002722802,0.000003676004,0.00002514868,0.00001007365,0.00007853499,0.9984192,0.0000849254,0.00003665668,0.001057738],"study_design_scores_gemma":[0.000010113,0.0001367298,0.00218094,0.000005296334,0.00001525419,0.0001422611,0.00001600137,0.001193055,0.993357,0.00005518896,0.002883581,0.000004577348],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896019,0.002528004,0.004064098,0.000105528,0.0000764702,0.00006403671,0.000668274,0.0001532444,0.002738439],"genre_scores_gemma":[0.9911849,0.0009736123,0.003973837,0.00007038063,0.00001288004,0.00004982103,0.0006071977,0.00003276508,0.003094715],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001515986,"threshold_uncertainty_score":0.005071461,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01605398850097399,"score_gpt":0.3145295781421058,"score_spread":0.2984755896411318,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}