{"id":"W4400324862","doi":"10.1038/s41589-024-01660-y","title":"Recruitment of FBXO22 for targeted degradation of NSD2","year":2024,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":false,"ca_institutions":"Structural Genomics Consortium; Princess Margaret Cancer Centre; York University; University of Toronto; University Health Network","funders":"Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill; Division of Chemistry; Natural Sciences and Engineering Research Council of Canada; Genentech; Ontario Genomics Institute; Government of Canada; National Cancer Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; McGill University; Florida Department of Health; Bayer; Cancer Research Society; Genome Canada; Fonds de Recherche du Québec - Santé; Leukemia and Lymphoma Society; Canadian Institutes of Health Research; National Science Foundation; National Institutes of Health; Ontario Genomics; U.S. Department of Health and Human Services; Princess Margaret Cancer Foundation; Pfizer","keywords":"Cullin; Ubiquitin ligase; Ubiquitin; Methyltransferase; Epigenetics; Protein degradation; Biology; Chemistry; Histone; Mutation; Cell biology; Genetics; Biochemistry; Cancer research; Methylation; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000116518,0.00008885578,0.0001356092,0.00004256365,0.000009495024,0.000002738607,0.000110453,0.000504637,0.00001726764],"category_scores_gemma":[0.0002484381,0.00007168936,0.0001142202,0.00009289298,0.00006557275,0.000001989716,0.00003960969,0.0001213084,0.000001182556],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001082128,"about_ca_system_score_gemma":0.00004952274,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001796938,"about_ca_topic_score_gemma":7.138841e-7,"domain_scores_codex":[0.9993697,0.00002236297,0.0002149625,0.0002334793,0.00004728088,0.0001121888],"domain_scores_gemma":[0.999631,0.00003430397,0.00006147788,0.0001457663,0.00009791094,0.00002957424],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007483046,0.00002804078,0.00005755349,0.00006911594,0.00004373619,9.729299e-8,0.000005196747,2.403766e-7,0.9815525,0.005855919,0.003857337,0.008455382],"study_design_scores_gemma":[0.0001912394,0.000168782,0.00001439601,0.00001687067,0.00001124283,0.000001674991,0.000004869145,0.00002798988,0.8609632,0.0007155178,0.13782,0.00006417422],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9805315,0.01302301,0.003628579,0.0006847463,0.0006548031,0.0006440299,0.0002052643,0.00002475312,0.0006033799],"genre_scores_gemma":[0.9951349,0.0001132709,0.003058628,0.0001200868,0.0001715089,0.00006221347,0.001131392,0.00001026927,0.0001976612],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1339627,"threshold_uncertainty_score":0.3892222,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01853529800049043,"score_gpt":0.3160912100289077,"score_spread":0.2975559120284173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}