{"id":"W4400324862","doi":"10.1038/s41589-024-01660-y","title":"Recruitment of FBXO22 for targeted degradation of NSD2","year":2024,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":false,"ca_institutions":"Structural Genomics Consortium; Princess Margaret Cancer Centre; York University; University of Toronto; University Health Network","funders":"Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill; Division of Chemistry; Natural Sciences and Engineering Research Council of Canada; Genentech; Ontario Genomics Institute; Government of Canada; National Cancer Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; McGill University; Florida Department of Health; Bayer; Cancer Research Society; Genome Canada; Fonds de Recherche du Québec - Santé; Leukemia and Lymphoma Society; Canadian Institutes of Health Research; National Science Foundation; National Institutes of Health; Ontario Genomics; U.S. Department of Health and Human Services; Princess Margaret Cancer Foundation; Pfizer","keywords":"Cullin; Ubiquitin ligase; Ubiquitin; Methyltransferase; Epigenetics; Protein degradation; Biology; Chemistry; Histone; Mutation; Cell biology; Genetics; Biochemistry; Cancer research; Methylation; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002944646,0.0003529775,0.0003378005,0.0001667254,0.0004115141,0.0009447117,0.0002751065,0.0004170258,0.004047839],"category_scores_gemma":[0.0002530007,0.000236635,0.0002760905,0.0001264631,0.0002572023,0.0002326862,0.0003969565,0.0006347477,0.00145263],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00118537,"about_ca_system_score_gemma":0.0005774061,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00119854,"about_ca_topic_score_gemma":0.002492353,"domain_scores_codex":[0.9997588,0.00002604996,0.00002310103,0.00005797028,0.00007449427,0.00005954786],"domain_scores_gemma":[0.9999167,0.00001141326,0.00001196866,0.00001242194,0.00001125417,0.00003632318],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002580235,0.00005879654,0.0003004498,0.00006144438,0.000009591802,0.0001025101,0.000023603,0.0002045148,0.9949544,0.0004925211,0.0007190813,0.002815105],"study_design_scores_gemma":[0.0000171102,0.00002978837,0.001324034,0.000004219928,0.000002605964,0.0001180939,0.00001684384,0.001805844,0.9901761,0.00003369556,0.006465548,0.000006078783],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9737691,0.002925701,0.00957047,0.0008423527,0.0002033054,0.0001281391,0.0009790277,0.0005069281,0.01107512],"genre_scores_gemma":[0.9791393,0.0008214553,0.005852534,0.0002368316,0.00002006739,0.00009026775,0.001038388,0.00007862922,0.01272253],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004047839,"threshold_uncertainty_score":0.0135414,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01853529800049043,"score_gpt":0.3160912100289077,"score_spread":0.2975559120284173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}