{"id":"W4400332537","doi":"10.1002/alz.14081","title":"Perivascular spaces, plasma GFAP, and speeded executive function in neurodegenerative diseases","year":2024,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Cerebrospinal fluid and hydrocephalus","field":"Neuroscience","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; Bruyère; The Scarborough Hospital; Public Health Ontario; Baycrest Hospital; McMaster University; Hamilton Health Sciences; Centre for Addiction and Mental Health; Toronto Western Hospital; Thunder Bay Regional Research Institute; Sunnybrook Hospital; Western University; Nova Scotia Health Authority; University of Ottawa; McGill University; Health Sciences Centre; Occupational Cancer Research Centre; University Health Network; University of Toronto; Montreal Neurological Institute and Hospital; Ontario Brain Institute; Toronto Rehabilitation Institute; St. Michael's Hospital; Sunnybrook Health Science Centre","funders":"Canadian Institutes of Health Research; HORIZON EUROPE Framework Programme; Olav Thon Stiftelsen; Department of Psychiatry, University of Toronto; Temerty Family Foundation; UK Dementia Research Institute; Fondation Brain Canada; Familjen Erling-Perssons Stiftelse; European Commission; Hjärnfonden; Linda C. Campbell Foundation; Queen's University; University of Toronto; Faculty of Health Sciences, Queen's University; University College London; National Institute for Health and Care Research; London Health Sciences Foundation; Centre for Addiction and Mental Health Foundation; Consortium canadien en neurodégénérescence associée au vieillissement; Government of Ontario; EU Joint Programme – Neurodegenerative Disease Research; Alzheimer's Association; Stiftelsen för Gamla Tjänarinnor; Centre for Addiction and Mental Health; University of Ottawa; Vetenskapsrådet; Cure Alzheimer's Fund; McMaster University; Alzheimer Society; BrightFocus Foundation; Alzheimer's Drug Discovery Foundation","keywords":"Neurodegeneration; Glial fibrillary acidic protein; Hyperintensity; Frontotemporal dementia; Biomarker; Medicine; Dementia; White matter; Executive dysfunction; Neuroscience; Pathology; Disease; Perivascular space; Neuroimaging; Psychology; Internal medicine; Magnetic resonance imaging; Cognition; Biology; Neuropsychology; Radiology; Immunohistochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001140264,0.0005660437,0.0004158797,0.0007291551,0.0004034542,0.0007265388,0.0004787267,0.0003729398,0.00156051],"category_scores_gemma":[0.003334382,0.000184425,0.0006269723,0.0006136026,0.0005793107,0.0004292134,0.0005904976,0.0004544257,0.0001154063],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000590272,"about_ca_system_score_gemma":0.0008438331,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01584358,"about_ca_topic_score_gemma":0.0150348,"domain_scores_codex":[0.9995626,0.0001351825,0.00003304399,0.000108821,0.000105001,0.00005543388],"domain_scores_gemma":[0.9975269,0.000427037,0.001465567,0.000158597,0.0001999275,0.0002218723],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003506236,0.00003901833,0.995542,0.00003696511,0.000294508,0.00009309305,0.0001161274,0.0001057314,0.0003194185,0.00005215328,0.00005301334,0.002997334],"study_design_scores_gemma":[0.000007348606,0.0001107169,0.9990632,0.00001522518,0.00006175298,0.0001307536,0.00007505241,0.0001802408,0.000103861,0.0001540321,0.00009460201,0.00000334466],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978897,0.001081495,0.0001718681,0.00009001812,0.000005584202,0.000009685163,0.0002710285,0.0000051754,0.0004755242],"genre_scores_gemma":[0.9994505,0.0001627634,0.0001449604,0.00001326741,0.000008871116,0.0000060795,0.00009643866,8.585984e-7,0.0001162376],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01584358,"threshold_uncertainty_score":0.03150272,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02484425506679637,"score_gpt":0.2579795616521732,"score_spread":0.2331353065853768,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}