{"id":"W4400345395","doi":"10.1016/j.jtct.2024.06.030","title":"Tandem Autologous Stem Cell Transplantation Does Not Benefit High-Risk Myeloma Patients in the Maintenance Era: Real-World Results from The Canadian Myeloma Research Group Database","year":2024,"lang":"en","type":"article","venue":"Transplantation and Cellular Therapy","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hôpital Maisonneuve-Rosemont; Memorial University of Newfoundland; University of Alberta; Université de Montréal; University of Saskatchewan; Queen Elizabeth II Health Sciences Centre; Dalhousie University; Saskatchewan Cancer Agency; CancerCare Manitoba; Ottawa Hospital; Ottawa Regional Cancer Foundation; Juravinski Cancer Centre; Institute of Cancer Research; Saint John Regional Hospital; BC Cancer Agency; University of Calgary; Princess Margaret Cancer Centre; University of British Columbia; Alberta Cancer Foundation; McGill University","funders":"","keywords":"Medicine; Multiple myeloma; Transplantation; Autologous stem-cell transplantation; Internal medicine; Oncology; Bortezomib; Regimen; Maintenance therapy; Cyclophosphamide; Cohort; Surgery; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0013902,0.0002830608,0.0002699968,0.0003493622,0.0006220265,0.000224274,0.000267981,0.0001361322,0.00005495996],"category_scores_gemma":[0.00001063496,0.0001478386,0.000084966,0.0006122147,0.0001905843,0.0001920068,0.000007400393,0.0008167627,0.0000424771],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000203164,"about_ca_system_score_gemma":0.000224481,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.3013533,"about_ca_topic_score_gemma":0.6596752,"domain_scores_codex":[0.9966589,0.0006876423,0.0004773406,0.0006458948,0.0008898354,0.000640347],"domain_scores_gemma":[0.9980509,0.001054086,0.00006525841,0.0004613709,0.000116757,0.000251578],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0250286,0.001180547,0.3448961,0.000934967,0.0008442937,0.01111491,0.07673422,0.00004446692,0.01948792,0.008116768,0.001160629,0.5104566],"study_design_scores_gemma":[0.00896657,0.0004233423,0.9724621,0.0003873974,0.0001251311,0.00001930763,0.0007439185,0.0007010739,0.01391397,0.0004299261,0.001603684,0.0002236334],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890898,0.0008234343,0.000115935,0.003001268,0.0001833225,0.001544712,0.004067337,0.00005910097,0.001115053],"genre_scores_gemma":[0.9681422,0.02482336,0.0001373795,0.0003377129,0.0001209868,0.0001385656,0.005699265,0.0000389151,0.0005616357],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6275659,"threshold_uncertainty_score":0.703299,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03335916754604702,"score_gpt":0.2918436707820194,"score_spread":0.2584845032359724,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}