{"id":"W4400348797","doi":"10.1021/acsnano.3c12981","title":"Quantitative Visualization of Lipid Nanoparticle Fusion as a Function of Formulation and Process Parameters","year":2024,"lang":"en","type":"article","venue":"ACS Nano","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; iCo Therapeutics (Canada); University of British Columbia","funders":"Social Sciences and Humanities Research Council of Canada; British Columbia Knowledge Development Fund; Natural Sciences and Engineering Research Council of Canada; NanoMedicines Innovation Network; Mitacs; Canadian Institutes of Health Research; University of British Columbia; Canada Foundation for Innovation","keywords":"Förster resonance energy transfer; Nanoparticle; Drug delivery; Fusion; Chemistry; Nanotechnology; Biophysics; Biological system; Materials science; Fluorescence; Physics; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007180897,0.00005105206,0.00006296223,0.00004209966,0.00001694946,0.0000089414,0.00002886993,0.0000520328,0.000005729612],"category_scores_gemma":[0.0000404877,0.0000449789,0.00002270393,0.0001010926,0.00002573205,0.00001221162,0.00001886903,0.00001387605,0.000003009158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002837794,"about_ca_system_score_gemma":0.00002716095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001176874,"about_ca_topic_score_gemma":0.000005428479,"domain_scores_codex":[0.9996004,0.00001727745,0.0001339027,0.0001273484,0.00006514735,0.00005593233],"domain_scores_gemma":[0.9997673,0.00001063491,0.0000478533,0.00006626649,0.00009359999,0.00001434938],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001779994,0.00002147215,0.001096965,0.0000811045,0.00002877947,1.679508e-7,0.0002544164,0.00006852962,0.9948437,0.0008079118,0.00006380353,0.002555191],"study_design_scores_gemma":[0.0001260311,0.001185376,0.001406508,0.0000612091,0.00002414962,0.000001731494,0.0001716112,0.001145352,0.9952739,0.0004210396,0.000131093,0.00005203674],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972579,0.0006337035,0.001793143,0.00001832567,0.00008276077,0.00008520897,0.000004074652,0.000005850197,0.0001190313],"genre_scores_gemma":[0.9996281,0.0001354707,0.00007136135,0.00002392828,0.00001541766,0.000005906533,0.00003824764,0.000006035979,0.00007555785],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002503154,"threshold_uncertainty_score":0.1834186,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01601877357089067,"score_gpt":0.3010064719185016,"score_spread":0.284987698347611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}