{"id":"W4400350043","doi":"10.1101/2024.07.03.24309466","title":"Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling","year":2024,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health; Dalhousie University","funders":"Janssen Biotech; National Center for Research Resources; National Institute of Mental Health; Norwegian Institute of Public Health; Faculty of Medicine and Health, University of Sydney; National Institute on Alcohol Abuse and Alcoholism; Health Research Council of New Zealand; Medizinische Fakultät der Albert-Ludwigs-Universität Freiburg; National Health and Medical Research Council; Menzies Centre for Australian Studies, King's College London, University of London; Medical Research Council; Helse Sør-Øst RHF; Fakultet for medisin og helsevitenskap, Norges Teknisk-Naturvitenskapelige Universitet; Stanley Center for Psychiatric Research, Broad Institute; Center for Clinical and Translational Science, University of Utah; Genentech; National Institutes of Health; Amsterdam Neuroscience; Siemens Healthineers; Lotto New Zealand; Chinese Society of Clinical Oncology; University College London Hospitals NHS Foundation Trust; Universität Duisburg-Essen; Gratama Stichting; Forskningsrådet om Hälsa, Arbetsliv och Välfärd; H. Lundbeck A/S; Humboldt-Universität zu Berlin; Tallinna Tehnikaülikool; Celgene; Helse Midt-Norge; Universität Mannheim; Vetenskapsrådet; Novo Nordisk; Physicians' Services Incorporated Foundation; Jacobs Foundation; Business Finland; Örebro Universitet; Vanderbilt University; GGZ Drenthe; Universität Greifswald; GGZ inGeest; Eesti Teadusagentuur; ZonMw; Institute of Psychiatry, Psychology and Neuroscience, King’s College London; Canterbury Medical Research Foundation; Koninklijke Nederlandse Akademie van Wetenschappen; Rijksuniversiteit Groningen; Centre Hospitalier Universitaire Vaudois; Universiteit Leiden; Norges Forskningsråd; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Deutsche Forschungsgemeinschaft; Erasmus Universitair Medisch Centrum Rotterdam; South African Medical Research Council; University of Bristol; U.S. Department of Defense; NordForsk; National Center for Advancing Translational Sciences; Bundesministerium für Bildung und Forschung; European Science Foundation; University of Oxford; Universitetet i Oslo; Lundbeckfonden; Accare; NIHR Maudsley Biomedical Research Centre; Dalhousie University; Albert-Ludwigs-Universität Freiburg; Massachusetts General Hospital; Scottish Funding Council; University College London; Academy of Finland; Imperial College London; King's College London; University of Toronto; Department of Health and Social Care; National Institute for Health and Care Research; Jan Dekker Stichting; Tartu Ülikool; Maze Therapeutics; Universitätsklinikum Essen; GlaxoSmithKline; Trond Mohn stiftelse; Nord universitet; QIMR Berghofer Medical Research Institute; Vanderbilt University Medical Center; Huntsman Cancer Institute; Johns Hopkins University; Wellcome Trust; Sanofi; Leids Universitair Medisch Centrum; Foundation for the National Institutes of Health; National Alliance for Research on Schizophrenia and Depression; Bristol-Myers Squibb; Helsingin Yliopisto; Freie Universität Berlin; Aarhus Universitetshospital; Universidade Federal do Rio Grande do Sul; Harvard University; University of Cape Town; Georgia Clinical and Translational Science Alliance; Virginia Commonwealth University; Brown University; Philipps-Universität Marburg; U.S. Department of Veterans Affairs; Karolinska Institutet; Cure Kids; Yale University; Universitair Medisch Centrum Groningen; Office of Research and Development; Centre for Addiction and Mental Health Foundation; Universitetet i Bergen; Université de Lausanne; National Science Foundation; University of Miami; Rivierduinen; Pfizer; GGZ Friesland; Helse- og Omsorgsdepartementet; Biogen; Norges Teknisk-Naturvitenskapelige Universitet; Scottish Government; Sigrid Juséliuksen Säätiö; Queensland University of Technology; UK Research and Innovation; Stiftelsen Kristian Gerhard Jebsen; Aarhus Universitet; Cancer Research UK; South London and Maudsley NHS Foundation Trust; Ministry of Cultural Affairs; Broad Institute; National Cancer Institute; European Regional Development Fund; International OCD Foundation; Fundação de Amparo à Pesquisa do Estado de São Paulo; Canadian Institutes of Health Research; Else Kröner-Fresenius-Stiftung; European Commission; AstraZeneca; Vrije Universiteit Amsterdam; Texas AgriLife Research; University of California, San Diego; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Brain and Behavior Research Foundation; University of Otago","keywords":"GABAergic; Genome-wide association study; Anxiety; Association (psychology); Biology; Genetic association; Genome; Psychiatry; Neuroscience; Genetics; Evolutionary biology; Psychology; Single-nucleotide polymorphism; Gene; Genotype; Psychotherapist; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001333992,0.0002968945,0.0004817176,0.0001325447,0.00007571828,0.00004586086,0.000261538,0.000351812,0.00001143755],"category_scores_gemma":[0.0007241706,0.0002895322,0.0001355597,0.000134747,0.00005611718,0.000002997978,0.000849211,0.0003871223,0.00000883021],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006613853,"about_ca_system_score_gemma":0.00007754942,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003312297,"about_ca_topic_score_gemma":0.002066567,"domain_scores_codex":[0.9974053,0.0006282859,0.0006939099,0.0007606841,0.000194991,0.0003168211],"domain_scores_gemma":[0.9988005,0.0001637469,0.0004787323,0.0003941834,0.000102853,0.00006001757],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0000174431,0.0002469781,0.983586,0.0001704289,0.0002970019,0.00001261157,0.0005566967,0.001316684,0.01340989,0.000004216345,0.000249241,0.0001328528],"study_design_scores_gemma":[0.0006937233,0.0001936722,0.9936299,0.00006556144,0.0001859779,0.00000223563,0.0009340178,0.00006173332,0.001559397,0.0008203799,0.001487032,0.0003663746],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940669,0.004036891,0.00005373397,0.000407136,0.0004094945,0.0004486729,0.00005312189,0.00001892343,0.0005051163],"genre_scores_gemma":[0.9958081,0.002827968,0.0001225392,0.00004348472,0.0001993222,0.00005504402,0.0001862272,0.00004400322,0.0007133642],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0118505,"threshold_uncertainty_score":0.9999557,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0157244977634601,"score_gpt":0.2672257977460659,"score_spread":0.2515012999826057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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