{"id":"W4400350393","doi":"10.1021/jacsau.4c00359","title":"Gonococcal Mimitope Vaccine Candidate Forms a Beta-Hairpin Turn and Binds Hydrophobically to a Therapeutic Monoclonal Antibody","year":2024,"lang":"en","type":"article","venue":"JACS Au","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Lawrence Berkeley National Laboratory; Basic Energy Sciences; National Institute of Allergy and Infectious Diseases; European Research Council; Università degli Studi di Firenze; Office of Science; National Institutes of Health; Ministero dell'Università e della Ricerca; University of Toronto; University College Dublin; Dipartimenti di Eccellenza; European Commission; U.S. Department of Energy; Diamond Light Source; Università degli Studi di Napoli Federico II","keywords":"Monoclonal antibody; Turn (biochemistry); Virology; Chemistry; Microbiology; Antibody; Biology; Immunology; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001036294,0.0003067881,0.0002904193,0.0001227496,0.0001393197,0.0002229903,0.0002362782,0.0003853597,0.001192302],"category_scores_gemma":[0.00009487046,0.00009839358,0.0001903697,0.00008989793,0.000119612,0.0001834948,0.0001879146,0.0003843645,0.0003045796],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003256671,"about_ca_system_score_gemma":0.0002399928,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003454068,"about_ca_topic_score_gemma":0.0005798957,"domain_scores_codex":[0.9999399,0.0000099015,0.000002001304,0.00001248986,0.00002001398,0.00001565846],"domain_scores_gemma":[0.9999781,0.000003416698,0.000005550473,0.000001591143,0.000005209574,0.00000612226],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001008809,0.00007452571,0.0007680042,0.00006810746,0.0000203948,0.0001675725,0.00001177626,0.001421534,0.9899113,0.000681883,0.0002327042,0.006541347],"study_design_scores_gemma":[0.0001235601,0.002022563,0.004523532,0.00002954689,0.00007494862,0.0007232716,0.00006524678,0.02221125,0.9513346,0.0004677146,0.01840357,0.00002012839],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986438,0.002555322,0.007319717,0.0001845684,0.00006806177,0.00007460773,0.000170631,0.0001187735,0.003070297],"genre_scores_gemma":[0.986093,0.001357532,0.009248324,0.0002609804,0.00001596305,0.00007504246,0.0005997545,0.00001215675,0.00233722],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001192302,"threshold_uncertainty_score":0.003988624,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01783390293588079,"score_gpt":0.339578249763558,"score_spread":0.3217443468276773,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}