{"id":"W4400350393","doi":"10.1021/jacsau.4c00359","title":"Gonococcal Mimitope Vaccine Candidate Forms a Beta-Hairpin Turn and Binds Hydrophobically to a Therapeutic Monoclonal Antibody","year":2024,"lang":"en","type":"article","venue":"JACS Au","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Lawrence Berkeley National Laboratory; Basic Energy Sciences; National Institute of Allergy and Infectious Diseases; European Research Council; Università degli Studi di Firenze; Office of Science; National Institutes of Health; Ministero dell'Università e della Ricerca; University of Toronto; University College Dublin; Dipartimenti di Eccellenza; European Commission; U.S. Department of Energy; Diamond Light Source; Università degli Studi di Napoli Federico II","keywords":"Monoclonal antibody; Turn (biochemistry); Virology; Chemistry; Microbiology; Antibody; Biology; Immunology; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004045546,0.0003335161,0.00052987,0.0003230248,0.0001673916,0.0001469494,0.0001885749,0.0001498597,0.0003695238],"category_scores_gemma":[0.00003739225,0.0002193188,0.0001899087,0.0004981412,0.0000886585,0.0001245977,0.0002305804,0.0005378345,0.000395659],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001310532,"about_ca_system_score_gemma":0.0004253793,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009262074,"about_ca_topic_score_gemma":0.0002400439,"domain_scores_codex":[0.9977373,0.00004911988,0.0004260036,0.0006152968,0.000434051,0.000738246],"domain_scores_gemma":[0.9987349,0.0001561223,0.00003407698,0.0003441591,0.00009048837,0.0006402568],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.006431486,0.0007527464,0.1990982,0.002183205,0.002055779,0.002506944,0.003131677,0.0000221176,0.4729875,0.01584294,0.01901145,0.275976],"study_design_scores_gemma":[0.002154697,0.002609631,0.3441699,0.000704187,0.0002662305,0.001395306,0.00010832,0.007818262,0.01001348,0.001783007,0.6282607,0.0007162538],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9635378,0.002726991,0.0001909831,0.02698593,0.0003142119,0.000775411,0.00006836537,0.0001124242,0.005287913],"genre_scores_gemma":[0.9895342,0.0004921898,0.0004334003,0.001835417,0.0007505175,0.00007679827,0.0001107611,0.0000581211,0.00670857],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6092493,"threshold_uncertainty_score":0.8943563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01783390293588079,"score_gpt":0.339578249763558,"score_spread":0.3217443468276773,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}