{"id":"W4400357265","doi":"10.1016/j.cell.2024.06.011","title":"Early rhombic lip Protogenin+ve stem cells in a human-specific neurovascular niche initiate and maintain group 3 medulloblastoma","year":2024,"lang":"en","type":"article","venue":"Cell","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Children's Hospital; Ontario Institute for Cancer Research; Jewish General Hospital; McGill University; McGill University Health Centre; Sinai Health System; Princess Margaret Cancer Centre; Lunenfeld-Tanenbaum Research Institute; BC Cancer Agency; SickKids Foundation; University Health Network; University of Toronto; Hospital for Sick Children","funders":"National Cancer Institute; National Institutes of Health; Brain Tumour Charity; Canadian Cancer Society; Cancer Research UK; Entertainment Industry Foundation; Stand Up To Cancer; Hospital for Sick Children; Genome British Columbia; Government of Canada; Swifty Foundation; Ontario Institute for Cancer Research; Genome Canada; Government of Ontario; National Institute of Neurological Disorders and Stroke; University of Pittsburgh; Ontario Research Foundation; Canadian Cancer Society Research Institute; Matthew Larson Foundation for Pediatric Brain Tumors; University of Toronto; V Foundation for Cancer Research; Canadian Institutes of Health Research; Terry Fox Research Institute; Cancer Prevention and Research Institute of Texas; Pediatric Brain Tumor Foundation; American Association for Cancer Research","keywords":"Biology; Medulloblastoma; Neurovascular bundle; Niche; Stem cell; Cell biology; Anatomy; Genetics; Ecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001106759,0.0001496001,0.0001765198,0.0003722605,0.0002166787,0.0003793064,0.0001641512,0.0002197953,0.002634663],"category_scores_gemma":[0.0001269608,0.0001570458,0.0001652163,0.0001433837,0.0002064719,0.0002678677,0.0003513788,0.0006294784,0.0008693956],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000276419,"about_ca_system_score_gemma":0.0001820209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000836932,"about_ca_topic_score_gemma":0.001990375,"domain_scores_codex":[0.9998976,0.00001301609,0.000005744049,0.00001707572,0.00002925444,0.00003739267],"domain_scores_gemma":[0.9998935,0.00002220245,0.00001671024,0.0000179368,0.0000120299,0.00003754538],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001254578,0.00001594124,0.0008827539,0.00001271518,0.000003407665,0.0002384919,0.00008056041,0.00007400426,0.9953009,0.001366829,0.00009786634,0.001801077],"study_design_scores_gemma":[0.00001795667,0.0001169948,0.01680285,0.000007392583,0.00001158525,0.0007696306,0.0002175556,0.001180008,0.9726303,0.0002765633,0.007965718,0.000003525992],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920197,0.0003525914,0.003510582,0.00004665203,0.00001488828,0.00002983936,0.0002477707,0.0001050291,0.003672973],"genre_scores_gemma":[0.9910448,0.0001026277,0.001610916,0.00002724419,0.000005804645,0.00002437051,0.0004307951,0.00005338489,0.006700144],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002634663,"threshold_uncertainty_score":0.008813858,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01186293348211307,"score_gpt":0.2440422212040914,"score_spread":0.2321792877219783,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}