{"id":"W4400357265","doi":"10.1016/j.cell.2024.06.011","title":"Early rhombic lip Protogenin+ve stem cells in a human-specific neurovascular niche initiate and maintain group 3 medulloblastoma","year":2024,"lang":"en","type":"article","venue":"Cell","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Children's Hospital; Ontario Institute for Cancer Research; Jewish General Hospital; McGill University; McGill University Health Centre; Sinai Health System; Princess Margaret Cancer Centre; Lunenfeld-Tanenbaum Research Institute; BC Cancer Agency; SickKids Foundation; University Health Network; University of Toronto; Hospital for Sick Children","funders":"National Cancer Institute; National Institutes of Health; Brain Tumour Charity; Canadian Cancer Society; Cancer Research UK; Entertainment Industry Foundation; Stand Up To Cancer; Hospital for Sick Children; Genome British Columbia; Government of Canada; Swifty Foundation; Ontario Institute for Cancer Research; Genome Canada; Government of Ontario; National Institute of Neurological Disorders and Stroke; University of Pittsburgh; Ontario Research Foundation; Canadian Cancer Society Research Institute; Matthew Larson Foundation for Pediatric Brain Tumors; University of Toronto; V Foundation for Cancer Research; Canadian Institutes of Health Research; Terry Fox Research Institute; Cancer Prevention and Research Institute of Texas; Pediatric Brain Tumor Foundation; American Association for Cancer Research","keywords":"Biology; Medulloblastoma; Neurovascular bundle; Niche; Stem cell; Cell biology; Anatomy; Genetics; Ecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004099216,0.0002766524,0.000217236,0.0001997527,0.00007581015,0.0001548927,0.0002766585,0.0002939519,0.00004861731],"category_scores_gemma":[0.000005639493,0.0002904654,0.0001526831,0.0003154917,0.0001081248,0.000009088664,0.0003085748,0.0004587605,0.0000700635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006094137,"about_ca_system_score_gemma":0.00008863601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000371381,"about_ca_topic_score_gemma":0.0000456338,"domain_scores_codex":[0.9978075,0.000220826,0.0002979379,0.000848913,0.0002892469,0.0005355931],"domain_scores_gemma":[0.999211,0.00001894147,0.00004100958,0.0005115419,0.00004829606,0.000169214],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006803988,0.0000667702,0.00001156097,0.0001549856,0.00004011951,0.0003355095,0.000135617,0.00003223168,0.9964851,0.0003064296,0.0005303791,0.001833278],"study_design_scores_gemma":[0.0009380796,0.0007049622,0.0001107927,0.00008282031,0.00001935091,0.00004618667,0.00009749423,0.0002232318,0.9633403,0.0004007845,0.03369964,0.0003363209],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.984494,0.005783061,0.007263438,0.00005155055,0.0002430687,0.001307908,0.00002166156,0.00005170906,0.0007835889],"genre_scores_gemma":[0.9974057,0.0008427441,0.0001693166,0.0001140399,0.0001604366,0.0002741437,0.00003292212,0.0001017157,0.0008989872],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03316926,"threshold_uncertainty_score":0.9999548,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01186293348211307,"score_gpt":0.2440422212040914,"score_spread":0.2321792877219783,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}