{"id":"W4400358441","doi":"10.1136/bmjopen-2023-078335","title":"Protocol for a systematic review with prospective individual patient data meta-analysis in EGFR-mutant NSCLC with brain metastases to assess the effect of SRS+osimertinib compared to osimertinib alone: the STARLET Collaboration","year":2024,"lang":"en","type":"review","venue":"BMJ Open","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Sunnybrook Health Science Centre; Health Sciences Centre; University of British Columbia; BC Cancer Agency","funders":"National Medical Research Council; Medical Research Council; National University Health System; National University Cancer Institute, Singapore; Royal Australian and New Zealand College of Radiologists; Cancer Australia; AstraZeneca","keywords":"Osimertinib; Medicine; Meta-analysis; Protocol (science); Oncology; Internal medicine; Cancer; Epidermal growth factor receptor; Pathology; Erlotinib","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.07998861,0.007315205,0.02217892,0.01037097,0.003465864,0.008181055,0.006455371,0.01001012,0.09834581],"category_scores_gemma":[0.1275881,0.005973698,0.02931143,0.01126343,0.004335516,0.00810177,0.005800208,0.007838507,0.01150217],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01403118,"about_ca_system_score_gemma":0.03547631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005811275,"about_ca_topic_score_gemma":0.01056251,"domain_scores_codex":[0.9393017,0.03095473,0.01467983,0.006487708,0.006295651,0.00228036],"domain_scores_gemma":[0.9456483,0.01988068,0.01318113,0.00837331,0.01089322,0.002023382],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"systematic_review","study_design_scores_codex":[0.01774266,0.0001911026,0.0009975556,0.8807181,0.02070069,0.0003408956,0.0008319846,0.001587082,0.001362393,0.005180153,0.05170852,0.01863883],"study_design_scores_gemma":[0.1441992,0.002488085,0.008075283,0.4574469,0.06317657,0.0006201039,0.0009713007,0.004418483,0.003266704,0.02247847,0.2919074,0.0009515358],"study_design_candidate":"systematic_review","study_design_consensus":"systematic_review","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.0005289607,0.002606041,0.0022276,0.000989733,0.0008362118,0.9740767,0.01732394,0.0003256277,0.001085115],"genre_scores_gemma":[0.0007715705,0.0005337183,0.003196877,0.0004479216,0.00004727389,0.9934549,0.001068375,0.00002821502,0.0004511519],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.09834581,"threshold_uncertainty_score":0.4230253,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.299132496793843,"score_gpt":0.52105213210786,"score_spread":0.221919635314017,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}