{"id":"W4400378519","doi":"10.1101/2024.06.30.601409","title":"Cerebral Microvascular Density, Permeability of the Blood-Brain Barrier, and Neuroinflammatory Responses Indicate Early Aging Characteristics in a Marfan Syndrome Mouse Model","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Connective tissue disorders research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institutes of Health","keywords":"Neuroinflammation; Marfan syndrome; Dentate gyrus; Medicine; Blood–brain barrier; Pathology; Internal medicine; Endocrinology; Hippocampus; Inflammation; Central nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001141373,0.0004662318,0.0005433453,0.000283345,0.0001118267,0.0001344185,0.0007014964,0.0005000284,0.000005484089],"category_scores_gemma":[0.001063221,0.0004621906,0.0002259398,0.0002790142,0.0004653456,0.00000924501,0.003106017,0.0009990353,0.000003662515],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007580154,"about_ca_system_score_gemma":0.0008470297,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001284673,"about_ca_topic_score_gemma":0.00003115481,"domain_scores_codex":[0.9968771,0.0005225352,0.0005466873,0.001191306,0.0003621371,0.0005002871],"domain_scores_gemma":[0.9976813,0.0000561773,0.0002435898,0.001578481,0.0002671265,0.0001732976],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007591048,0.00008004751,0.1478239,0.000724175,0.000177469,0.00005820649,0.00003571992,0.00001986628,0.8509476,0.00004524317,0.000009805343,0.000002121717],"study_design_scores_gemma":[0.0003867535,0.00005883651,0.4692859,0.0002037337,0.00008441722,3.543076e-7,0.000004050977,0.0004860475,0.529035,0.00001238361,0.00005129556,0.0003912013],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968338,0.001418583,0.0000444549,0.0002891947,0.0001429164,0.0008466553,0.0003791544,0.00004381433,0.000001396784],"genre_scores_gemma":[0.999275,0.0001774596,0.0001811216,0.00007247688,0.00004819024,0.000078807,0.00000101401,0.0001276958,0.00003819894],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3219126,"threshold_uncertainty_score":0.999783,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009886450043977021,"score_gpt":0.2281604039286077,"score_spread":0.2182739538846307,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}