{"id":"W4400386690","doi":"10.1101/2024.07.05.602286","title":"CBP/p300 lysine acetyltransferases inhibit HIV-1 expression in latently infected T-cells","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Acetyltransferases; Human immunodeficiency virus (HIV); Virology; Lysine; Biology; Acetylation; Medicine; Genetics; Amino acid; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001468786,0.000313002,0.0003104705,0.0002247496,0.0001640243,0.0003176296,0.000372597,0.0002333883,0.002962522],"category_scores_gemma":[0.0001363747,0.0001349992,0.0001885386,0.0001458549,0.0001791983,0.0001369308,0.0001610085,0.0009428284,0.001173494],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003010893,"about_ca_system_score_gemma":0.0002841154,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00115984,"about_ca_topic_score_gemma":0.001245277,"domain_scores_codex":[0.999877,0.00001639146,0.00001028988,0.00001444071,0.00004506703,0.00003692745],"domain_scores_gemma":[0.9999238,0.00002192593,0.000009444429,0.0000123434,0.00001039252,0.00002205548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002931243,0.0001064501,0.00009376423,0.00003404775,0.000006138043,0.00002937704,0.000007883125,0.00008713729,0.9962209,0.0001044493,0.0002272873,0.002789457],"study_design_scores_gemma":[0.00004551023,0.0003447401,0.00110588,0.00000275027,0.000007829949,0.00004644397,0.000005749157,0.0009008913,0.9957372,0.00004599972,0.001755156,0.000001973702],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9770313,0.006497429,0.005462705,0.0003652317,0.0001729214,0.00008720695,0.001418701,0.0005100223,0.008454524],"genre_scores_gemma":[0.9791222,0.001632246,0.003654956,0.0001161543,0.0000545317,0.00007255941,0.001632905,0.00007834231,0.01363607],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002962522,"threshold_uncertainty_score":0.009910643,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01163917188064355,"score_gpt":0.2256711290021627,"score_spread":0.2140319571215192,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}