{"id":"W4400389474","doi":"10.1007/s11010-024-05059-0","title":"Lack of cellular prion protein causes Amyloid β accumulation, increased extracellular vesicle abundance, and changes to exosome biogenesis proteins","year":2024,"lang":"en","type":"article","venue":"Molecular and Cellular Biochemistry","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; University of Calgary","funders":"Canadian Institutes of Health Research; Hans-Gabriel och Alice Trolle-Wachtmeisters stiftelse för medicinsk forskning; Alberta Innovates; Vetenskapsrådet; Connaught Fund; Linköpings Universitet; Alzheimerfonden; Hjärnfonden; Region Östergötland; Demensfonden; Banting Research Foundation","keywords":"Exosome; ESCRT; Microvesicles; Biogenesis; Cell biology; Endosome; Biology; Extracellular vesicle; Extracellular; Intracellular; Biochemistry; microRNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001473621,0.0004711391,0.0003885631,0.0004096053,0.000151374,0.0003202003,0.0002088331,0.0005111665,0.001368633],"category_scores_gemma":[0.0001479514,0.000214342,0.0003463507,0.0002689468,0.0004277859,0.0002043465,0.0002648538,0.0008221972,0.0004462737],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001772888,"about_ca_system_score_gemma":0.0001350073,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004794475,"about_ca_topic_score_gemma":0.0004119504,"domain_scores_codex":[0.9996413,0.00005256366,0.00007484353,0.00008619598,0.00008030412,0.00006481566],"domain_scores_gemma":[0.9996,0.00006106202,0.0001305245,0.00005412685,0.00003187813,0.0001224656],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000190263,0.00005014533,0.0001473999,0.00002224661,0.000006525775,0.0001243904,0.00001020396,0.00001734775,0.9991459,0.0000275892,0.00001796355,0.0002400339],"study_design_scores_gemma":[0.00003438834,0.0009385973,0.01486333,0.00001136026,0.00003449043,0.001097408,0.00008400295,0.0007408156,0.9806575,0.00006428775,0.001460967,0.00001278771],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962597,0.000691834,0.001531908,0.00006850555,0.00004605785,0.0000266092,0.000745779,0.00007913763,0.0005504825],"genre_scores_gemma":[0.9945727,0.0005255556,0.001418291,0.00005262856,0.00001468561,0.0000607021,0.0008047732,0.00004073745,0.002509977],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001368633,"threshold_uncertainty_score":0.00457859,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01573078452913174,"score_gpt":0.2663545136863053,"score_spread":0.2506237291571736,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}