{"id":"W4400406602","doi":"10.3390/biom14070808","title":"West Nile Virus-Induced Expression of Senescent Gene Lgals3bp Regulates Microglial Phenotype within Cerebral Cortex","year":2024,"lang":"en","type":"article","venue":"Biomolecules","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institute of Neurological Disorders and Stroke; National Institute on Aging; National Institutes of Health; Washington University in St. Louis","keywords":"Neuroinflammation; Microglia; Biology; Downregulation and upregulation; Immunology; Inflammation; Transcriptome; Senescence; Gene expression; Phenotype; Central nervous system; Virology; Neuroscience; Cell biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001221128,0.0002272112,0.0001957697,0.0001831443,0.0001345563,0.0001396149,0.0002470902,0.00009243627,0.0002281755],"category_scores_gemma":[0.0001139195,0.000198748,0.0001080964,0.0003473714,0.0001028996,0.0001819438,0.0001049507,0.0001245006,0.0002234551],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002472496,"about_ca_system_score_gemma":0.00009869918,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001786352,"about_ca_topic_score_gemma":0.00001567909,"domain_scores_codex":[0.9981109,0.0001883797,0.0004509838,0.0006108338,0.0003985305,0.0002403977],"domain_scores_gemma":[0.9992751,0.00006884704,0.0001418599,0.0003521898,0.00005039308,0.0001115808],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004760474,0.00006367775,0.000003785433,0.00004485091,0.000002737335,0.00008180906,0.0002002903,0.0000154139,0.9919797,0.006698822,0.0004097395,0.0004515547],"study_design_scores_gemma":[0.0002476525,0.0001193019,0.00007877561,0.00005795607,0.00001320572,0.00004915947,0.00001815548,0.001958802,0.9963554,0.0002768081,0.0006196485,0.000205104],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962322,0.0001105825,0.0009934945,0.0003074213,0.001470074,0.0002811027,0.0000870787,0.0002939508,0.000224066],"genre_scores_gemma":[0.9979811,0.00003179217,0.0007997567,0.0003619164,0.0001724247,0.00001252636,0.00001581663,0.00004916255,0.000575472],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006422014,"threshold_uncertainty_score":0.810471,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02758332364336731,"score_gpt":0.2634141088644488,"score_spread":0.2358307852210815,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}