{"id":"W4400407754","doi":"10.1007/s13346-024-01654-2","title":"Synergistic effects of thermosensitive liposomal doxorubicin, mild hyperthermia, and radiotherapy in breast cancer management: an orthotopic mouse model study","year":2024,"lang":"en","type":"article","venue":"Drug Delivery and Translational Research","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Hyperthermia; Doxorubicin; Medicine; Liposome; Radiation therapy; Breast cancer; Cancer research; Cancer; Pharmacology; Chemotherapy; Oncology; Internal medicine; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002165513,0.0001145124,0.0001393921,0.0002281956,0.00008080518,0.00004254795,0.00007031117,0.00004178868,0.00001589942],"category_scores_gemma":[0.000001094385,0.0001039991,0.00002267463,0.0002485994,0.00009167669,0.0001535632,0.000008996984,0.0002025685,0.000001210219],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002093678,"about_ca_system_score_gemma":0.00002882901,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002217246,"about_ca_topic_score_gemma":0.0003265551,"domain_scores_codex":[0.9990889,0.00007684632,0.0001462915,0.0002397158,0.0002494827,0.0001987854],"domain_scores_gemma":[0.9994654,0.0003072408,0.00000548843,0.0001084187,0.00004668281,0.00006678722],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0004925561,0.001360407,0.03842618,0.003295375,0.001397062,0.0001932704,0.03822731,0.1097583,0.5224072,0.01959916,0.00007438008,0.2647687],"study_design_scores_gemma":[0.001704175,0.00007156312,0.1611689,0.000282752,0.00008236368,0.000008352328,0.0008329652,0.8297226,0.003648165,0.002034927,0.0001029223,0.0003403178],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937234,0.004863604,0.0003078756,0.000129414,0.00002025726,0.0005244936,0.00008490895,0.00004603841,0.0002999915],"genre_scores_gemma":[0.9968662,0.002644041,0.0001400696,0.00001281027,0.0000407594,0.0001216952,0.00001117465,0.0000271734,0.000136127],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7199643,"threshold_uncertainty_score":0.4240959,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01793331694779602,"score_gpt":0.2937127725565775,"score_spread":0.2757794556087815,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}