{"id":"W4400408103","doi":"10.1371/journal.ppat.1012370","title":"Extraneural infection route restricts prion conformational variability and attenuates the impact of quaternary structure on infectivity","year":2024,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; Canadian Food Inspection Agency; University of Calgary","funders":"Canadian Wildlife Health Cooperative; University of Alberta; Alberta Prion Research Institute; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Canadian Food Inspection Agency","keywords":"Chronic wasting disease; Infectivity; Prion protein; Biology; Gene isoform; Inoculation; Virology; Virus; Scrapie; Pathology; Immunology; Gene; Disease; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008862626,0.0003501265,0.0002185757,0.0001196545,0.00006848318,0.0003366633,0.0001904489,0.0001992906,0.0006886494],"category_scores_gemma":[0.0001375992,0.00008217282,0.0001354647,0.00004995672,0.0001718022,0.0002002094,0.0001739993,0.0004708989,0.0002298825],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009560298,"about_ca_system_score_gemma":0.0001692561,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004036506,"about_ca_topic_score_gemma":0.0008892912,"domain_scores_codex":[0.9999033,0.00001632739,0.00001020046,0.00002105445,0.00002426134,0.00002477961],"domain_scores_gemma":[0.9998527,0.00001992042,0.00004193922,0.00002398252,0.00002113467,0.00004031156],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007825923,0.00003580831,0.0001837708,0.00002394759,0.000002226553,0.00002324365,0.000009694782,0.00001838824,0.9986779,0.00002467153,0.00001739075,0.0009046654],"study_design_scores_gemma":[0.00002644005,0.002153086,0.02564317,0.00003488539,0.00004682761,0.0006594139,0.0000872522,0.0009085638,0.9681437,0.0000693411,0.002217615,0.000009682307],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974657,0.000658036,0.0008807666,0.00003620289,0.00001069246,0.00001756579,0.00011119,0.00004230589,0.0007774943],"genre_scores_gemma":[0.9955193,0.0008028779,0.001600884,0.00004249213,0.00001008979,0.00002434887,0.0002924649,0.0000158672,0.001691713],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006886494,"threshold_uncertainty_score":0.00230372,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01222426173977199,"score_gpt":0.2725430871966666,"score_spread":0.2603188254568947,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}