{"id":"W4400408647","doi":"10.1016/j.jhepr.2024.101168","title":"Loss of biochemical response at any time worsens outcomes in UDCA-treated patients with primary biliary cholangitis","year":2024,"lang":"en","type":"article","venue":"JHEP Reports","topic":"Liver Diseases and Immunity","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Dalhousie University; University of British Columbia; University of Calgary; University of Ottawa; Western University; University of Toronto; Université de Sherbrooke; Queen's University; Toronto General Hospital; University Health Network; Université de Montréal; University of Saskatchewan; St. Michael's Hospital","funders":"Allergan; Grifols; Ipsen; Novo Nordisk; Swedish Orphan Biovitrum; European Association for the Study of the Liver; Vir Biotechnology; Intercept Pharmaceuticals; Pfizer; Incyte; Bristol-Myers Squibb; Dr. Falk Pharma; CSL Behring; Ultragenyx Pharmaceutical; Canadian Liver Foundation; Celgene; PSC Partners Seeking a Cure; Gilead Sciences; American Association for the Study of Liver Diseases; Kowa Company; Sanofi; Genesis Pharma; LifeArc; Falk Foundation","keywords":"Ursodeoxycholic acid; Medicine; Internal medicine; Liver transplantation; Primary biliary cirrhosis; Gastroenterology; Alkaline phosphatase; Liver disease; Cohort; Bilirubin; Transplantation; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002038058,0.0001459304,0.0003513783,0.0001578811,0.0000228544,0.00001095189,0.00003739478,0.0000825714,0.0002575641],"category_scores_gemma":[0.000157734,0.0001010251,0.0001109449,0.0002852275,0.00009734183,0.0000878936,0.00008934618,0.0001468296,0.00002824972],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002166325,"about_ca_system_score_gemma":0.0001565797,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001381927,"about_ca_topic_score_gemma":0.000001947335,"domain_scores_codex":[0.9987821,0.00005889863,0.0003857316,0.0002842715,0.0002986451,0.0001903784],"domain_scores_gemma":[0.9991171,0.0001095113,0.00009217835,0.0004770305,0.00008029979,0.0001238468],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001663964,0.0004826938,0.9836813,0.0001546246,0.0001197778,0.004735338,0.0001211683,3.597082e-7,0.006834916,3.217415e-7,0.001985277,0.000220212],"study_design_scores_gemma":[0.0006925047,0.0002397934,0.9943435,0.0003900868,0.000128758,0.000212129,0.000008290977,0.000009136812,0.00294894,0.000007790096,0.0009044572,0.0001146357],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979714,0.000416555,2.207332e-7,0.0002043452,0.00008302753,0.0003658159,0.00005520369,0.00007412009,0.0008293717],"genre_scores_gemma":[0.9955823,0.00001351199,0.00005404947,0.0000942215,0.00001829792,0.0000108153,0.000297665,0.00002608993,0.003902978],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01066213,"threshold_uncertainty_score":0.4119685,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00515738763793972,"score_gpt":0.230152378719982,"score_spread":0.2249949910820423,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}