{"id":"W4400412405","doi":"10.1016/j.nbd.2024.106596","title":"Frequency-dependent seizure-suppressing effects of optogenetic activation of septal inhibitory cells in mesial temporal lobe epilepsy","year":2024,"lang":"en","type":"article","venue":"Neurobiology of Disease","topic":"Photoreceptor and optogenetics research","field":"Neuroscience","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research; Savoy Foundation","keywords":"Optogenetics; Stimulation; Ictal; Epilepsy; Neuroscience; Inhibitory postsynaptic potential; Deep brain stimulation; Temporal lobe; Pilocarpine; Status epilepticus; Hippocampus; Medicine; Internal medicine; Psychology; Parkinson's disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001503001,0.0001753482,0.0003039583,0.0003368743,0.00002924411,0.00001156373,0.0003222194,0.0001171289,0.00005919717],"category_scores_gemma":[0.0003052802,0.0001651593,0.0001768431,0.0003389973,0.0004678923,0.0000996348,0.0001427886,0.0002463904,0.000006754387],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003419575,"about_ca_system_score_gemma":0.0002893175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003020149,"about_ca_topic_score_gemma":0.000002881992,"domain_scores_codex":[0.9979674,0.0005032637,0.0004467207,0.000489709,0.0002960663,0.0002968786],"domain_scores_gemma":[0.9988471,0.0005517931,0.000128345,0.0002889355,0.00004562387,0.0001382598],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002076398,0.0002604936,0.0102832,0.0007491702,0.000009179676,0.00002552786,0.0001354019,0.00025858,0.9876236,0.00006186511,0.0000586454,0.0003267186],"study_design_scores_gemma":[0.0004820737,0.000305814,0.01471036,0.000204364,0.00002363582,9.954099e-7,0.000008051658,0.0002928787,0.9835818,0.0002601167,0.00001591345,0.000113996],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982283,0.0002599898,0.00004587543,0.00003373018,0.0006679359,0.0004562942,0.0001326923,0.00002314605,0.0001520587],"genre_scores_gemma":[0.9996808,0.00007179503,0.00006343935,0.00003915347,0.00005527933,0.0000232232,0.00001155509,0.00002434045,0.00003039533],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00442716,"threshold_uncertainty_score":0.6735001,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01631864442888049,"score_gpt":0.2842620205940843,"score_spread":0.2679433761652039,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}