{"id":"W4400412960","doi":"10.1016/j.canlet.2024.217108","title":"Targeting of human cancer stem cells predicts efficacy and toxicity of FDA-approved oncology drugs","year":2024,"lang":"en","type":"article","venue":"Cancer Letters","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer; McMaster University","funders":"CIHR Skin Research Training Centre; Canadian Institutes of Health Research; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University; Canada Research Chairs","keywords":"Cancer stem cell; Medicine; Stem cell; Context (archaeology); Oncology; Cancer; Drug; Pharmacology; Clinical trial; Induced pluripotent stem cell; Cancer research; Adverse effect; Internal medicine; Biology; Gene; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002156372,0.0001317992,0.0002272754,0.00006081813,0.00003824061,0.00001213977,0.000179974,0.0001166957,0.00003117162],"category_scores_gemma":[0.000007042402,0.000122902,0.00006146749,0.0001027212,0.0002679737,0.000004960556,0.0001497614,0.0001372999,0.000001279271],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006725515,"about_ca_system_score_gemma":0.0001505994,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001512558,"about_ca_topic_score_gemma":0.00002205405,"domain_scores_codex":[0.99885,0.00008208504,0.0002626717,0.0003728416,0.0001720058,0.0002603553],"domain_scores_gemma":[0.9995542,0.00003246405,0.00009087651,0.0001890117,0.00005748985,0.00007595871],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006032395,0.00002997294,0.0003912277,0.0004819265,0.0001308399,0.000005813444,0.0003143166,0.0003566928,0.982497,0.000006455997,0.01139135,0.004334126],"study_design_scores_gemma":[0.0004981005,0.0001696254,0.0002068272,0.0001204251,0.00003365269,9.364285e-7,0.00005007185,0.0002559514,0.9823796,0.000001930967,0.0161672,0.0001156814],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914361,0.006434506,0.0001348933,0.001092854,0.0002707099,0.0002667136,0.0000930649,0.0000116477,0.0002595153],"genre_scores_gemma":[0.9978821,0.001026279,0.00005832515,0.0003200398,0.0002242609,0.0000476324,0.00001725124,0.00002435559,0.0003997387],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006446023,"threshold_uncertainty_score":0.5011798,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01674756208787339,"score_gpt":0.3056053616406258,"score_spread":0.2888577995527524,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}