{"id":"W4400415914","doi":"10.1038/s41417-024-00795-3","title":"Long-term severe hypoxia adaptation induces non-canonical EMT and a novel Wilms Tumor 1 (WT1) isoform","year":2024,"lang":"en","type":"article","venue":"Cancer Gene Therapy","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Fonds de Recherche du Québec - Santé; Stem Cell Network; Government of Canada; Canadian Institutes of Health Research; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Cancer Research Society","keywords":"Cancer research; Biology; Hypoxia (environmental); Wilms' tumor; Prostate cancer; Gene isoform; Cell culture; Colorectal cancer; Cancer; Gene; Genetics; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000102742,0.0001739655,0.0001549973,0.0001176436,0.000118162,0.0001614382,0.00009884941,0.0001318169,0.0006546049],"category_scores_gemma":[0.00008065716,0.00007474153,0.0001321848,0.0000871598,0.0001530537,0.0001048333,0.0001271926,0.0003465578,0.0001934303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001743336,"about_ca_system_score_gemma":0.0001854134,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003095262,"about_ca_topic_score_gemma":0.000640559,"domain_scores_codex":[0.9999328,0.000007876931,0.000007362595,0.00001849693,0.00002001191,0.00001347242],"domain_scores_gemma":[0.9999316,0.00000973559,0.00002989287,0.000007131355,0.000006595218,0.00001503837],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003391885,0.00001106848,0.0002559815,0.00001818628,0.000001480575,0.00004681841,0.000007767046,0.00004789642,0.9986701,0.00005948318,0.00003543985,0.0008119385],"study_design_scores_gemma":[0.000009294049,0.0003844314,0.00794778,0.000004559088,0.00001206005,0.0007710775,0.00002259476,0.0008124385,0.985366,0.00003529873,0.004630323,0.000004073013],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934731,0.0009236081,0.004298017,0.00009273168,0.00002346156,0.00003710946,0.00041811,0.00007218858,0.0006615032],"genre_scores_gemma":[0.9927065,0.001071581,0.002866554,0.00004799627,0.0000141151,0.00004483012,0.0009020928,0.0000205769,0.002325891],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006546049,"threshold_uncertainty_score":0.002189875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01811113587502821,"score_gpt":0.272999924273827,"score_spread":0.2548887883987988,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}