{"id":"W4400415914","doi":"10.1038/s41417-024-00795-3","title":"Long-term severe hypoxia adaptation induces non-canonical EMT and a novel Wilms Tumor 1 (WT1) isoform","year":2024,"lang":"en","type":"article","venue":"Cancer Gene Therapy","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Fonds de Recherche du Québec - Santé; Stem Cell Network; Government of Canada; Canadian Institutes of Health Research; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Cancer Research Society","keywords":"Cancer research; Biology; Hypoxia (environmental); Wilms' tumor; Prostate cancer; Gene isoform; Cell culture; Colorectal cancer; Cancer; Gene; Genetics; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006574695,0.0001799508,0.0001391801,0.00003715756,0.00006949846,0.00005712709,0.0001183736,0.0001492912,0.00004067649],"category_scores_gemma":[0.000002446749,0.0001376937,0.00007745517,0.0001153138,0.00008826797,0.000009579259,0.00003343733,0.0001398505,0.000006653485],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000426922,"about_ca_system_score_gemma":0.0003321519,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007329983,"about_ca_topic_score_gemma":0.00005521663,"domain_scores_codex":[0.9991102,0.00001217638,0.0001565141,0.0003851134,0.0001106654,0.0002252823],"domain_scores_gemma":[0.9996552,0.000006812279,0.00004232883,0.0001619652,0.00004153173,0.00009212395],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000217097,0.00002494259,0.0003882115,0.00003951013,0.0002338267,0.0000111412,0.0002031998,0.0002312875,0.9178823,0.00001712307,0.0006784027,0.08007298],"study_design_scores_gemma":[0.002448309,0.0009121143,0.02372054,0.0002607341,0.00007435532,0.0002295184,0.0001112635,0.0008808813,0.9445284,0.00009882298,0.02599571,0.0007393747],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9586642,0.03909933,0.0008536077,0.0002843616,0.0005197616,0.0001903091,0.00003822862,0.00002179673,0.000328342],"genre_scores_gemma":[0.9772596,0.02026607,0.0001212694,0.0006345856,0.0005864246,0.00007925729,0.00005649906,0.00003467489,0.0009616106],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0793336,"threshold_uncertainty_score":0.5614988,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01811113587502821,"score_gpt":0.272999924273827,"score_spread":0.2548887883987988,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}