{"id":"W4400430008","doi":"10.3389/fimmu.2024.1397117","title":"LncRNA Nostrill promotes interferon-γ-stimulated gene transcription and facilitates intestinal epithelial cell-intrinsic anti-Cryptosporidium defense","year":2024,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; McMaster University","keywords":"Biology; Intestinal epithelium; Cell biology; Intracellular; Interferon; Chromatin; Transcription factor; STAT1; Gene; Immunology; Epithelium; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001154991,0.0002015913,0.0001920428,0.0001453637,0.0001621042,0.0003375783,0.000135119,0.0001967122,0.0025151],"category_scores_gemma":[0.00009701498,0.0001066656,0.0003026538,0.0001161032,0.0002412507,0.0002030543,0.0002590444,0.000471072,0.0005055604],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002704302,"about_ca_system_score_gemma":0.0002893683,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003556533,"about_ca_topic_score_gemma":0.0009303214,"domain_scores_codex":[0.9998816,0.00001402138,0.00001011524,0.00003579236,0.00002953305,0.00002889289],"domain_scores_gemma":[0.9998928,0.000013283,0.00003177499,0.00001036134,0.00001786622,0.00003377115],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001899436,0.00001768747,0.0005289179,0.0001021164,0.00000411653,0.000128115,0.00002781075,0.00004818877,0.9968402,0.000183629,0.0001739802,0.001755271],"study_design_scores_gemma":[0.0000509515,0.0004634071,0.03728129,0.00003732981,0.00004028259,0.0006545307,0.0001552812,0.001616006,0.9391359,0.0002207168,0.02032743,0.00001692331],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9717325,0.008828671,0.007341305,0.0006577001,0.0002891315,0.00006094234,0.001927193,0.0006488126,0.008513704],"genre_scores_gemma":[0.9890717,0.002092109,0.002299217,0.0001764753,0.00003992702,0.00003445901,0.001101888,0.00004658837,0.005137511],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0025151,"threshold_uncertainty_score":0.008413851,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007285250276564737,"score_gpt":0.2281886124499128,"score_spread":0.2209033621733481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}