{"id":"W4400430429","doi":"10.3389/fped.2024.1431008","title":"Hyperosmolarity in children with hyperammonemia: a risk of brain herniation at the start of renal replacement therapy","year":2024,"lang":"en","type":"article","venue":"Frontiers in Pediatrics","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Hyperammonemia; Medicine; Osmotic concentration; Osmole; Renal replacement therapy; Intensive care unit; Internal medicine; Cerebral edema; Blood urea nitrogen; Neonatal intensive care unit; Urine osmolality; Anesthesia; Creatinine; Gastroenterology; Pediatrics; Urinary system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005458977,0.0001074708,0.0001544101,0.00009475043,0.00002242652,0.000008233488,0.0001378233,0.0001071209,0.000007530742],"category_scores_gemma":[0.00005521439,0.00007546027,0.0000509372,0.0002869604,0.0000732769,0.000003598887,0.00005042379,0.0001265726,4.869567e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001111161,"about_ca_system_score_gemma":0.00009901175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002090381,"about_ca_topic_score_gemma":0.0002334981,"domain_scores_codex":[0.9990519,0.0001164028,0.0002523922,0.0002510113,0.000183589,0.0001446889],"domain_scores_gemma":[0.9995531,0.00001748263,0.00009579369,0.0002820383,0.00002934462,0.00002222289],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003198823,0.00006714406,0.9808217,0.00001940577,0.00005672377,4.550583e-7,0.0002041914,0.0008904859,0.001962202,0.000005629623,0.009162913,0.006489264],"study_design_scores_gemma":[0.003788444,0.0007359487,0.9538431,0.00002108203,0.0001218459,0.000006169144,0.0003668194,0.0005252641,0.01987383,0.0004038478,0.01997558,0.0003380819],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9696119,0.02726954,0.002416779,0.0001009962,0.0001575636,0.0002911607,0.00008053065,0.000003215809,0.00006826308],"genre_scores_gemma":[0.9881071,0.009568519,0.001805361,0.00006391884,0.00009180331,0.00002018256,0.0001095107,0.00001619444,0.000217356],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02697862,"threshold_uncertainty_score":0.3077181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00379173631877454,"score_gpt":0.2062182405151189,"score_spread":0.2024265041963444,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}