{"id":"W4400430898","doi":"10.1101/2024.07.04.601982","title":"Transcriptomic Hallmarks of Mortality Reveal Universal and Specific Mechanisms of Aging, Chronic Disease, and Rejuvenation","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Health, Environment, Cognitive Aging","field":"Environmental Science","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Rejuvenation; Transcriptome; Disease; Biology; Computational biology; Evolutionary biology; Genetics; Medicine; Gene; Gene expression; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009553986,0.0003755237,0.000465686,0.0001575846,0.00008190128,0.00004249436,0.0002538165,0.0002410736,0.0001405619],"category_scores_gemma":[0.00003770505,0.0004283625,0.00009094418,0.0002402616,0.0004873326,0.0001585068,0.0006612019,0.0005640822,0.00001425704],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006362789,"about_ca_system_score_gemma":0.0001798959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002641805,"about_ca_topic_score_gemma":0.00002193528,"domain_scores_codex":[0.9973022,0.0001867264,0.0005399112,0.001138318,0.0004731891,0.0003596254],"domain_scores_gemma":[0.9985592,0.0000469665,0.0003650107,0.0006985087,0.00002881379,0.0003014353],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00002808954,0.0001067808,0.02328009,0.001940317,0.0001384804,0.00005401299,0.00006789732,0.0001461918,0.9721224,0.001980844,0.00009160721,0.00004333545],"study_design_scores_gemma":[0.0005143062,0.00007422608,0.8711646,0.001014125,0.0003032622,2.798243e-8,0.00001179317,0.001337099,0.1240859,0.000314393,0.0006054548,0.0005748417],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934971,0.002311028,0.002475605,0.0002198318,0.000276039,0.000770274,0.0003405278,0.00006902754,0.00004061177],"genre_scores_gemma":[0.9966524,0.001847205,0.001288981,0.00004590682,0.00005845894,0.0000309383,7.246962e-7,0.00006841151,0.000006993863],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8480365,"threshold_uncertainty_score":0.9998168,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01321285484891093,"score_gpt":0.2231761642569185,"score_spread":0.2099633094080075,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}