{"id":"W4400431855","doi":"10.1016/j.celrep.2024.114417","title":"The TSC22D, WNK, and NRBP gene families exhibit functional buffering and evolved with Metazoa for cell volume regulation","year":2024,"lang":"en","type":"article","venue":"Cell Reports","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Hospital for Sick Children; Toronto Rehabilitation Institute; SickKids Foundation; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Hospital for Sick Children; Canada Research Chairs; National Human Genome Research Institute; University of Toronto; Canada Foundation for Innovation; Canadian Institutes of Health Research; Genome Canada","keywords":"Gene family; Biology; Gene; Osmotic concentration; Osmotic shock; Cell biology; Kinase; Protein family; Gene duplication; Protein domain; Genetics; Gene expression; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006783601,0.0002858985,0.000161871,0.0003868138,0.0002499838,0.0002450008,0.0001879291,0.0001777899,0.0007651866],"category_scores_gemma":[0.0001454194,0.0001225223,0.0002363414,0.0002938787,0.0002874306,0.0002195415,0.0004418506,0.000208689,0.0003680467],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004331141,"about_ca_system_score_gemma":0.0003259084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001591487,"about_ca_topic_score_gemma":0.002692037,"domain_scores_codex":[0.9999268,0.000003968989,0.000005882407,0.00002569342,0.00002538757,0.00001227497],"domain_scores_gemma":[0.9999117,0.000006554412,0.00003189831,0.00001232194,0.0000142737,0.00002320105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005612812,0.000003908993,0.003223629,0.00003049803,0.000006387907,0.0002059087,0.00002637741,0.0001164708,0.9929996,0.0001619655,0.00003471699,0.003134368],"study_design_scores_gemma":[0.0000189955,0.0001181403,0.1739899,0.00002053453,0.00005779635,0.005056794,0.0001910306,0.004030075,0.7956373,0.0005081233,0.02033658,0.00003473125],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926372,0.00100736,0.003803712,0.00005977105,0.00001504061,0.00001206812,0.0007347798,0.0001236834,0.001606472],"genre_scores_gemma":[0.9906231,0.000512831,0.005039211,0.00003926269,0.000004669842,0.00001946931,0.001091906,0.00003281324,0.002636737],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001591487,"threshold_uncertainty_score":0.00316447,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005842652345030572,"score_gpt":0.1835218882420113,"score_spread":0.1776792358969807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}