{"id":"W4400451222","doi":"10.1016/j.steroids.2024.109469","title":"Synthesis and anticancer properties of a hybrid molecule with the testosterone and estradiol head-groups","year":2024,"lang":"en","type":"article","venue":"Steroids","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hôpital Saint-François d'Assise; Université du Québec à Trois-Rivières","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; National Institute of Environmental Health Sciences; Université Laval","keywords":"Testosterone (patch); Chemistry; Molecule; Head (geology); Stereochemistry; Internal medicine; Combinatorial chemistry; Pharmacology; Endocrinology; Medicine; Biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007382014,0.0001049609,0.0001030851,0.0000189536,0.0000414837,0.00003305485,0.00005461563,0.0000381951,0.000001252218],"category_scores_gemma":[0.000009487865,0.00005625273,0.00002125042,0.00004034511,0.0002409723,0.000004011299,0.00004749437,0.00007215764,8.955413e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003009356,"about_ca_system_score_gemma":0.00002690805,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009344456,"about_ca_topic_score_gemma":0.000003506319,"domain_scores_codex":[0.9995096,0.00003491335,0.00007523449,0.0001966847,0.00006529018,0.0001182579],"domain_scores_gemma":[0.9997749,0.00001465084,0.00001739869,0.0001416898,0.00001472168,0.00003658756],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008620782,0.00001353963,0.000618297,0.0001283536,0.0001210093,0.00001216304,0.0001129669,0.000002516664,0.994874,0.00003194622,0.000138312,0.003860659],"study_design_scores_gemma":[0.0001714957,0.000568815,0.0007590697,0.0001758754,0.00007249252,0.0001996873,0.00008342849,0.0001777852,0.9971808,0.000006898157,0.0004987579,0.0001048531],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9757589,0.0234187,0.00008611736,0.0003594356,0.00002263997,0.0001462766,0.000007112656,0.00001030344,0.0001905832],"genre_scores_gemma":[0.9991673,0.0005070883,0.00005153315,0.00005245518,0.0000396479,0.00002444635,0.000002214319,0.00001725402,0.000138077],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02340845,"threshold_uncertainty_score":0.229392,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006642236230103538,"score_gpt":0.2091040810552773,"score_spread":0.2024618448251737,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}