{"id":"W4400451454","doi":"10.21203/rs.3.rs-4656309/v1","title":"Immature dendritic cell-targeting mRNA vaccine expressing PfCSP enhances protective immune responses against Plasmodium liver infection","year":2024,"lang":"en","type":"preprint","venue":"Research Square","topic":"Malaria Research and Control","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"National Institutes of Health; Bloomberg Philanthropies; Johns Hopkins University","keywords":"Circumsporozoite protein; Virology; Immune system; Malaria vaccine; Immunology; Immunogen; Vaccination; Malaria; Plasmodium berghei; Biology; Antibody; Medicine; Plasmodium falciparum; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001695391,0.0003301329,0.0003101424,0.0001508447,0.0001010675,0.0002958138,0.0001193605,0.0003142396,0.002703471],"category_scores_gemma":[0.0002627962,0.0001076895,0.0001272295,0.00007954874,0.0001726496,0.0002083673,0.0001681731,0.0008532775,0.0008289902],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002199643,"about_ca_system_score_gemma":0.0002038106,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002769933,"about_ca_topic_score_gemma":0.00021466,"domain_scores_codex":[0.9998953,0.00001603677,0.000005150414,0.00002034962,0.00002332413,0.00003982189],"domain_scores_gemma":[0.9999275,0.00002120711,0.00001103975,0.000007298666,0.00001389012,0.00001897734],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007064376,0.0001293803,0.0001387634,0.00007136355,0.000005366962,0.00004525337,0.00001729377,0.0003073748,0.9914609,0.0002910857,0.0004993595,0.00632757],"study_design_scores_gemma":[0.0002181238,0.001636789,0.00222021,0.00001445223,0.0000402394,0.0002466521,0.00004300199,0.004494894,0.9857223,0.0003873251,0.004970311,0.000005859566],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884796,0.0007025332,0.004275918,0.0004359498,0.0002674441,0.00006914301,0.0004994032,0.0002078573,0.005062243],"genre_scores_gemma":[0.9897562,0.0004810136,0.003386471,0.0001569127,0.0000914427,0.0000358365,0.0006836061,0.00005937853,0.005349162],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002703471,"threshold_uncertainty_score":0.009043992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02769414288608106,"score_gpt":0.3524110396406383,"score_spread":0.3247168967545572,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}