{"id":"W4400454849","doi":"10.1001/jamanetworkopen.2024.19818","title":"Navigating Drug Interactions with Proton Pump Inhibitors","year":2024,"lang":"en","type":"letter","venue":"JAMA Network Open","topic":"Gastroesophageal reflux and treatments","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre","funders":"","keywords":"Drug; Pharmacology; Chemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002538066,0.0004833427,0.0006762734,0.00004568744,0.0001758503,0.0006033352,0.0003419875,0.0002652903,0.0003560573],"category_scores_gemma":[0.00002473659,0.0003259348,0.0001689475,0.0003729732,0.00006020834,0.000290807,0.0004112347,0.004747241,0.0007790469],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002608271,"about_ca_system_score_gemma":0.0001955747,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000217126,"about_ca_topic_score_gemma":0.00002330348,"domain_scores_codex":[0.9976789,0.0001128795,0.0004263489,0.0007056149,0.0004676807,0.0006085872],"domain_scores_gemma":[0.9988035,0.0001244738,0.0002441365,0.0005770516,0.0001055355,0.0001453033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001106982,0.00005715277,0.02147718,0.0004470335,0.000738502,0.01344439,0.0002094158,0.00001661781,6.215806e-7,0.000003160202,0.9566122,0.006883017],"study_design_scores_gemma":[0.001589382,0.0003645665,0.001709702,0.01204264,0.0008138733,0.0006036607,0.00003145124,0.00007619841,0.0001053489,0.000143072,0.982291,0.0002290859],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.05869426,0.0004152828,0.0000111619,0.8918288,0.002031576,0.00899718,0.00006905066,0.0002894626,0.03766328],"genre_scores_gemma":[0.2245616,0.00004274093,0.003868133,0.6201561,0.03573297,0.003926108,0.003735856,0.0004739309,0.1075025],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.2716726,"threshold_uncertainty_score":0.999999,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01950653389942658,"score_gpt":0.3245405933848707,"score_spread":0.3050340594854442,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}