{"id":"W4400457745","doi":"10.1128/mbio.01661-24","title":"Alternative ergosterol biosynthetic pathways confer antifungal drug resistance in the human pathogens within the <i>Mucor</i> species complex","year":2024,"lang":"en","type":"article","venue":"mBio","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; National Institute of Allergy and Infectious Diseases; Astellas Pharma Global Development; Astellas Pharma; Canadian Institute for Advanced Research","keywords":"Ergosterol; Mucor circinelloides; Sterol; Biology; Microbiology; Drug resistance; Azole; Antifungal drug; Mucor; Aspergillus; Biochemistry; Cholesterol; Candida albicans; Antifungal","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001144645,0.0002554125,0.0003425848,0.00008025474,0.0002754697,0.0001572419,0.0003875965,0.00006991394,0.0002667439],"category_scores_gemma":[0.0001183062,0.0001355492,0.0001857106,0.0003611806,0.0005407433,0.00008306153,0.00007108727,0.0005520841,0.0001242693],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001008285,"about_ca_system_score_gemma":0.0001108246,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001055156,"about_ca_topic_score_gemma":0.003379017,"domain_scores_codex":[0.9979002,0.0002405135,0.0004484005,0.0005048669,0.0005454746,0.0003605031],"domain_scores_gemma":[0.9986717,0.0003456143,0.00007753425,0.0007523746,0.00008769702,0.00006506033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000614561,0.0006534325,0.1040313,0.0008607488,0.0002446634,0.001971647,0.04164241,0.000004355187,0.5574511,0.2414237,0.05046644,0.0006356941],"study_design_scores_gemma":[0.002066743,0.0003381727,0.8210371,0.002030966,0.0003444345,0.0001093267,0.01531834,0.0008347648,0.03184544,0.02437299,0.1008051,0.0008966527],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9679343,0.001375452,0.00008268895,0.004568486,0.0003069561,0.0006871152,0.0001283195,0.00008856204,0.02482812],"genre_scores_gemma":[0.9920987,0.0000644699,0.00008265296,0.001620846,0.0002383213,0.0000306078,0.00004034739,0.00002970442,0.005794273],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7170057,"threshold_uncertainty_score":0.5527534,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05076644913166144,"score_gpt":0.2903731583837745,"score_spread":0.2396067092521131,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}