{"id":"W4400459211","doi":"10.1128/spectrum.00888-24","title":"Brilacidin, a host defense peptide mimetic, potentiates ibrexafungerp antifungal activity against the human pathogenic fungus <i>Aspergillus fumigatus</i>","year":2024,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Azrieli Foundation; Conselho Nacional de Desenvolvimento Científico e Tecnológico; International Development Research Centre; Fundação de Amparo à Pesquisa do Estado de São Paulo; Canadian Institutes of Health Research; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; GlaxoSmithKline","keywords":"Aspergillus fumigatus; Fungus; Pathogenic fungus; Microbiology; Antifungal; Biology; Host (biology); Aspergillosis; Filamentous fungus; Aspergillus; Immunology; Gene; Ecology; Genetics; Botany","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0006081862,0.0008191364,0.0008736406,0.0002960912,0.001247156,0.000237748,0.000793228,0.0007640625,0.001318065],"category_scores_gemma":[0.00004594198,0.0006047807,0.0007613892,0.0004596446,0.00166619,0.0002781681,0.0005310543,0.001487709,0.002877219],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001598439,"about_ca_system_score_gemma":0.0001709957,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003643275,"about_ca_topic_score_gemma":0.0002853339,"domain_scores_codex":[0.9958024,0.0006497248,0.0006359741,0.001274148,0.00005159446,0.001586136],"domain_scores_gemma":[0.9983564,0.0003988766,0.000221184,0.0008849634,0.00006561608,0.00007297398],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001392462,0.0001685271,0.0009090864,0.00007642578,0.0008419266,0.0001722703,0.000333279,0.000005912984,0.9588745,0.001580713,0.03629006,0.0006080043],"study_design_scores_gemma":[0.0009268911,0.0003645353,0.003673407,0.000214514,0.0003541897,0.002114308,0.0003011255,0.00001140932,0.8745134,0.0003040841,0.1162305,0.0009916064],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.968984,0.02071555,0.0001260226,0.002505853,0.002940758,0.0006466299,0.0008675733,0.0006135434,0.002600042],"genre_scores_gemma":[0.9855299,0.0006421324,0.00004208972,0.001154426,0.0003540388,0.00003438046,0.0005406839,0.0001203481,0.01158198],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08436114,"threshold_uncertainty_score":0.9996403,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008777829998568024,"score_gpt":0.2152036083495228,"score_spread":0.2064257783509548,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}