{"id":"W4400459211","doi":"10.1128/spectrum.00888-24","title":"Brilacidin, a host defense peptide mimetic, potentiates ibrexafungerp antifungal activity against the human pathogenic fungus <i>Aspergillus fumigatus</i>","year":2024,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Azrieli Foundation; Conselho Nacional de Desenvolvimento Científico e Tecnológico; International Development Research Centre; Fundação de Amparo à Pesquisa do Estado de São Paulo; Canadian Institutes of Health Research; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; GlaxoSmithKline","keywords":"Aspergillus fumigatus; Fungus; Pathogenic fungus; Microbiology; Antifungal; Biology; Host (biology); Aspergillosis; Filamentous fungus; Aspergillus; Immunology; Gene; Ecology; Genetics; Botany","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001231406,0.0003823907,0.0001813427,0.0001455113,0.0001109348,0.0001408037,0.0002173812,0.0002688461,0.001653561],"category_scores_gemma":[0.00008906165,0.00007502831,0.0001895679,0.00007058715,0.00011887,0.0001915807,0.000149685,0.000469046,0.0004535269],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001314443,"about_ca_system_score_gemma":0.0001079523,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001678128,"about_ca_topic_score_gemma":0.000158578,"domain_scores_codex":[0.9999292,0.00001997643,0.000007859659,0.00001033803,0.00001288817,0.00001979754],"domain_scores_gemma":[0.9999593,0.000007317849,0.0000109273,0.000004015552,0.000004597579,0.00001369647],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005913189,0.0002073022,0.0001345957,0.0001418129,0.000009353896,0.0001365599,0.00001180548,0.0001425236,0.992928,0.00006997868,0.0002725786,0.00535413],"study_design_scores_gemma":[0.0002511577,0.007606952,0.003958805,0.00002273139,0.0000498268,0.00143511,0.00002210553,0.0008857299,0.9748268,0.0000475321,0.01087803,0.00001516504],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860076,0.008529156,0.001303466,0.0002692605,0.0001620655,0.00007900738,0.000317677,0.0001296987,0.003202116],"genre_scores_gemma":[0.9927026,0.002317102,0.002361136,0.0001871807,0.00006499669,0.00004467024,0.0004910319,0.000008798106,0.001822393],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001653561,"threshold_uncertainty_score":0.005531669,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008777829998568024,"score_gpt":0.2152036083495228,"score_spread":0.2064257783509548,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}