{"id":"W4400462455","doi":"10.1080/22221751.2024.2377606","title":"A long-term stable cold-chain-friendly HIV mRNA vaccine encoding multi-epitope viral protease cleavage site immunogens inducing immunogen-specific protective T cell immunity","year":2024,"lang":"en","type":"article","venue":"Emerging Microbes & Infections","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Public Health Agency of Canada","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; University of Nebraska-Lincoln","keywords":"HIV vaccine; Virology; Epitope; Biology; Immunogen; Immune system; Immunity; CD8; Immunology; Antigen; Vaccine trial; Antibody; Vaccination; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008735243,0.0002886307,0.0001176953,0.00009883112,0.0000896007,0.0001465054,0.000135082,0.0002687266,0.0004303433],"category_scores_gemma":[0.00008829349,0.0001007263,0.000161553,0.00006627423,0.000156635,0.0001797848,0.0001287379,0.0003504033,0.0002024263],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001977008,"about_ca_system_score_gemma":0.0002149859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002283372,"about_ca_topic_score_gemma":0.0003966466,"domain_scores_codex":[0.999922,0.00001063766,0.000006396171,0.00002037491,0.00002374884,0.00001678803],"domain_scores_gemma":[0.9999633,0.000004792189,0.00001290059,0.000003714109,0.000007554191,0.000007846192],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002135897,0.0000106794,0.00005653245,0.00002965869,0.000001657907,0.00002909167,0.000006350324,0.0001518539,0.9980785,0.0000847121,0.00001782744,0.00151179],"study_design_scores_gemma":[0.00001199664,0.0006852419,0.0006539016,0.000006026449,0.00001244281,0.0002346493,0.00001159084,0.001015422,0.9949226,0.00003261134,0.002408108,0.000005421175],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9743804,0.001487973,0.02213628,0.0001508444,0.00006137502,0.0001070787,0.0001908526,0.00008642497,0.001398815],"genre_scores_gemma":[0.9841192,0.0007130982,0.01265282,0.0000736457,0.0000165792,0.00005846587,0.0002972646,0.00001662173,0.002052439],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004303433,"threshold_uncertainty_score":0.001439631,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01356669306596931,"score_gpt":0.2617736034790684,"score_spread":0.2482069104130991,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}