{"id":"W4400477382","doi":"10.1101/2024.07.04.602118","title":"Hepatic Nrf1 ( <i>Nfe2l1</i> ) promotes VLDL dependent liver defense against sepsis","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Sepsis; Chemistry; Internal medicine; Pharmacology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001547352,0.0002671971,0.0002358482,0.0001854118,0.0001534478,0.0002168467,0.0001233823,0.000215063,0.003982094],"category_scores_gemma":[0.0001133773,0.00009596523,0.0002301294,0.0001376397,0.0001846528,0.0001886463,0.000183463,0.0004539494,0.001168996],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00020099,"about_ca_system_score_gemma":0.0001328399,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003284556,"about_ca_topic_score_gemma":0.0003969907,"domain_scores_codex":[0.9999247,0.0000137517,0.000005117057,0.0000186037,0.00001841058,0.00001955136],"domain_scores_gemma":[0.9999154,0.000008315919,0.00002200586,0.00001314152,0.00001489665,0.00002625878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001853634,0.00001900185,0.0002076294,0.00003397528,0.000003975988,0.00003045411,0.00000614312,0.00004567459,0.998435,0.0001193273,0.0001670481,0.000746502],"study_design_scores_gemma":[0.000027871,0.0001519942,0.007177157,0.00001209608,0.000009052608,0.0003120191,0.0000308312,0.0008941411,0.9863071,0.0001920124,0.004880583,0.000005170762],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9769662,0.001830278,0.01207537,0.0009659631,0.0001566072,0.00004022202,0.00311817,0.0004696969,0.004377392],"genre_scores_gemma":[0.9773356,0.0008201082,0.005030513,0.0002014067,0.00003597206,0.00004265413,0.0029951,0.0001293976,0.01340915],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003982094,"threshold_uncertainty_score":0.01332146,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0103635732593332,"score_gpt":0.214348543070935,"score_spread":0.2039849698116018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}