{"id":"W4400481895","doi":"10.1016/s2352-3026(24)00174-1","title":"Ruxolitinib in treatment-naive or corticosteroid-refractory paediatric patients with chronic graft-versus-host disease (REACH5): interim analysis of a single-arm, multicentre, phase 2 study","year":2024,"lang":"en","type":"article","venue":"The Lancet Haematology","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Medicine; Ruxolitinib; Interim analysis; Refractory (planetary science); Interim; Graft-versus-host disease; Internal medicine; Disease; Clinical trial; Surgery; Physical therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004820796,0.00109351,0.00237215,0.0002227986,0.0002921492,0.001670374,0.0006921036,0.001056315,0.002071937],"category_scores_gemma":[0.00283062,0.0003677517,0.003172341,0.0003645517,0.0006396637,0.001241569,0.0005199173,0.001836281,0.0003965752],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008329406,"about_ca_system_score_gemma":0.001154342,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008238535,"about_ca_topic_score_gemma":0.002535028,"domain_scores_codex":[0.9982433,0.0009934002,0.00008941744,0.0002245936,0.0001532581,0.000296038],"domain_scores_gemma":[0.9983766,0.0005504141,0.0005035918,0.0002061144,0.00007161996,0.0002916269],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8813938,0.002899169,0.01779322,0.001087412,0.012276,0.000301527,0.0002279043,0.004482532,0.005573581,0.0004704791,0.003234356,0.07026],"study_design_scores_gemma":[0.6360472,0.2209404,0.1143468,0.0003431909,0.01449018,0.000844225,0.0002330811,0.003601288,0.003201627,0.0009604067,0.004839641,0.0001520518],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919358,0.004316864,0.0005204151,0.0002780271,0.00007943276,0.000371898,0.00134851,0.00005987945,0.001089045],"genre_scores_gemma":[0.9930755,0.001162136,0.00101494,0.0005092613,0.00007799362,0.0005121971,0.002803547,0.0000228632,0.0008216349],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004820796,"threshold_uncertainty_score":0.02549511,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05126390704172114,"score_gpt":0.344091631847415,"score_spread":0.2928277248056939,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}