{"id":"W4400481895","doi":"10.1016/s2352-3026(24)00174-1","title":"Ruxolitinib in treatment-naive or corticosteroid-refractory paediatric patients with chronic graft-versus-host disease (REACH5): interim analysis of a single-arm, multicentre, phase 2 study","year":2024,"lang":"en","type":"article","venue":"The Lancet Haematology","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Medicine; Ruxolitinib; Interim analysis; Refractory (planetary science); Interim; Graft-versus-host disease; Internal medicine; Disease; Clinical trial; Surgery; Physical therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001863665,0.000287535,0.00131282,0.0005277537,0.00003635836,0.00001914053,0.0001542124,0.00007225238,0.000264017],"category_scores_gemma":[0.0001101068,0.0001622017,0.0001460225,0.001064383,0.0001522686,0.00008434784,0.00003057122,0.0001777428,0.00002973493],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002723239,"about_ca_system_score_gemma":0.0002228147,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001330251,"about_ca_topic_score_gemma":0.001039234,"domain_scores_codex":[0.9978648,0.0003479235,0.0006118761,0.0004504295,0.0002953991,0.0004295116],"domain_scores_gemma":[0.9979784,0.001029995,0.000185611,0.0005708357,0.00008186574,0.0001532453],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03697562,0.0195939,0.9082659,0.001924039,0.005627939,0.006396502,0.01568535,0.00004837488,0.0004483772,0.0001423644,0.00006710038,0.004824462],"study_design_scores_gemma":[0.1331033,0.03398757,0.7611655,0.001469292,0.05287099,0.0001967457,0.00620065,0.008534126,0.001029958,0.00002647837,0.0005122633,0.000903189],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963066,0.0009347283,0.0001095475,0.0002677389,0.0002418063,0.001637643,0.0002674662,0.00008298311,0.0001515107],"genre_scores_gemma":[0.999102,0.0001497825,0.00005207441,0.0000575148,0.00007736501,0.0001471421,0.0003351772,0.00003597032,0.00004299916],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1471005,"threshold_uncertainty_score":0.6614395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05126390704172114,"score_gpt":0.344091631847415,"score_spread":0.2928277248056939,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}