{"id":"W4400484024","doi":"10.1212/wnl.0000000000209620","title":"Association of Body Mass Index and Parkinson Disease","year":2024,"lang":"en","type":"article","venue":"Neurology","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Faculty of Medicine and Health, University of Sydney; Instituto de Salud Carlos III; MSD K.K.; Pfizer Japan; Novartis Pharma; Parkinsonfonden; Allergan; National Institutes of Health; Ipsen; Parkinson Vereniging; Sun Pharma; FP Pharmaceutical Corporation; Mitsubishi Tanabe Pharma Corporation; Medical Research Council; Servier; Skånes universitetssjukhus; Association France Parkinson; Norges Forskningsråd; European Commission; Fondazione Pierfranco e Luisa Mariani; Ministero della Salute; Helse Sør-Øst RHF; Sanofi K.K.; Eesti Teadusagentuur; Daiichi Sankyo Europe; Karolinska Institutet; ZonMw; Biogen; Agence Nationale de la Recherche; Idorsia Pharmaceuticals; H. Lundbeck A/S; Université Paris-Saclay; Department of Science and Technology, Ministry of Science and Technology, India; Fondation Roger de Spoelberch; South African Medical Research Council; Hersenstichting; Eli Lilly and Company; Radboud Universiteit; National Research Foundation; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; Ministerio de Ciencia e Innovación; University College London; Verily Life Sciences; Universiteit Stellenbosch; Parkinson's UK; Hellenic Foundation for Research and Innovation; General Secretariat for Research and Technology; Multiple System Atrophy Coalition; Bundesministerium für Bildung und Forschung; Nasjonalforeningen for Folkehelsen; Boehringer Ingelheim Japan; Fondazione Cariplo; Kissei; Alexion Pharmaceuticals; EVER Neuro Pharma; Nihon Medi-Physics; Pfizer; Université du Luxembourg; EU Joint Programme – Neurodegenerative Disease Research; Sunovion; Deutsche Forschungsgemeinschaft; Japan Agency for Medical Research and Development; Boston Scientific Corporation; Mylan; Multiple Sclerosis Society of Western Australia; Consortium canadien en neurodégénérescence associée au vieillissement; UCB Pharma; Meiji Seika Pharma; Michael J. Fox Foundation for Parkinson's Research; Teva Pharmaceutical Industries; U.S. Department of Defense; Sanofi; Japan Society for the Promotion of Science; Astellas Pharma; Horizon 2020 Framework Programme; Vetenskapsrådet; Eisai; Boston Scientific Japan; U.S. Department of Health and Human Services; GlaxoSmithKline; Ono Pharmaceutical; Takeda Pharmaceutical Company","keywords":"Mendelian randomization; Parkinson's disease; Body mass index; Disease; Medicine; Internal medicine; Association (psychology); Psychology; Oncology; Biology; Genetics; Genotype; Genetic variants; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00164256,0.0002731976,0.0002992683,0.0005011119,0.000214719,0.0003884049,0.0002341079,0.0003567851,0.002079351],"category_scores_gemma":[0.005402179,0.0001200673,0.0003369565,0.0005146092,0.0002515789,0.0001536405,0.000347315,0.0004706678,0.0001321843],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001494452,"about_ca_system_score_gemma":0.000231301,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001451091,"about_ca_topic_score_gemma":0.001381101,"domain_scores_codex":[0.9988778,0.0005763151,0.00008793754,0.0002753595,0.0001384935,0.00004401154],"domain_scores_gemma":[0.9963114,0.001769139,0.001166393,0.0004054884,0.0001839149,0.0001635904],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009200779,0.00005250356,0.9883808,0.00005407152,0.0006730121,0.0001028169,0.00004589546,0.0004138856,0.001826096,0.0002415802,0.0002037015,0.007085528],"study_design_scores_gemma":[0.00002356627,0.0001412503,0.997277,0.00001083004,0.0001485145,0.0003656549,0.00001167862,0.001044511,0.0003473044,0.0002811448,0.0003436728,0.000004886875],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937047,0.001490609,0.002380667,0.0002259185,0.00002740841,0.00001700245,0.0008849463,0.00004179168,0.001227017],"genre_scores_gemma":[0.9977971,0.0001409347,0.001391509,0.00003360216,0.00001633586,0.00001438135,0.0003702923,0.000007722279,0.0002281124],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002079351,"threshold_uncertainty_score":0.008686781,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008757159965259824,"score_gpt":0.2537514989401324,"score_spread":0.2449943389748725,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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