{"id":"W4400486007","doi":"10.1016/j.jtha.2024.06.023","title":"R1205H (Vicenza) causes conformational changes in the von Willebrand factor D′D3 domains and enhances von Willebrand factor binding to clearance receptors LRP1 and SR-AI","year":2024,"lang":"en","type":"article","venue":"Journal of Thrombosis and Haemostasis","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health; Science Foundation Ireland; Swedish Orphan Biovitrum; CSL Behring; ZonMw; Novo Nordisk; Sanofi; Pfizer","keywords":"Von Willebrand factor; Chemistry; Receptor; In vivo; LRP1; Endocrinology; Internal medicine; Binding site; Von Willebrand disease; Molecular biology; Platelet; Biochemistry; LDL receptor; Lipoprotein; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003254609,0.0005091148,0.0001792146,0.0002054045,0.0001465084,0.0002611355,0.0003552479,0.0004153233,0.001869222],"category_scores_gemma":[0.0001124629,0.0001693361,0.0004214172,0.0001049147,0.0002853966,0.000129031,0.0001273804,0.0005552595,0.0004924485],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002608573,"about_ca_system_score_gemma":0.000142288,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006177783,"about_ca_topic_score_gemma":0.0004689389,"domain_scores_codex":[0.9997965,0.0000520316,0.00002646282,0.00004035283,0.0000394431,0.00004525548],"domain_scores_gemma":[0.9998767,0.000015114,0.00005610655,0.00001642109,0.000005772898,0.00002985631],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007261792,0.0003802435,0.0003593825,0.00004223058,0.00002219199,0.0001580268,0.000009969825,0.0000496094,0.9962562,0.0002066975,0.0001086858,0.001680474],"study_design_scores_gemma":[0.0004244627,0.005987628,0.01079331,0.00001997768,0.00006772446,0.002771506,0.00005859102,0.001118715,0.9732247,0.00009159319,0.005427514,0.0000142226],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973744,0.0002958915,0.0008704701,0.0001216606,0.0000391179,0.00004170839,0.0002968001,0.0000437375,0.0009160817],"genre_scores_gemma":[0.9957437,0.0002828165,0.001346924,0.0001141544,0.00001884757,0.00003280762,0.0004784213,0.000021095,0.001961168],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001869222,"threshold_uncertainty_score":0.006253183,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04003054992426989,"score_gpt":0.3301987826854713,"score_spread":0.2901682327612014,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}