{"id":"W4400487525","doi":"10.1016/j.psj.2024.104078","title":"Oligodeoxynucleotides containing CpG motifs upregulate bactericidal activities of heterophils and enhance immunoprotection of neonatal broiler chickens against Salmonella Typhimurium septicemia","year":2024,"lang":"en","type":"article","venue":"Poultry Science","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Prince Edward Island; University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; Chicken Farmers of Saskatchewan","keywords":"CpG Oligodeoxynucleotide; Degranulation; Phagocytosis; Respiratory burst; Innate immune system; Biology; Immune system; CpG site; Microbiology; TLR9; Salmonella; Flow cytometry; Immunity; Immunology; Bacteria; Receptor; DNA methylation; Biochemistry; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002275198,0.0001381991,0.000159466,0.00009641009,0.00008417518,0.000057321,0.0002145853,0.00007997653,0.00001135168],"category_scores_gemma":[0.00005302826,0.0001257796,0.00006241729,0.0001920604,0.0005815382,0.00004627549,0.0001454559,0.0001022108,0.00000294789],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001192898,"about_ca_system_score_gemma":0.0001172843,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004896114,"about_ca_topic_score_gemma":0.000005640526,"domain_scores_codex":[0.9989731,0.00002559666,0.0002258839,0.0003843034,0.0001711651,0.0002199159],"domain_scores_gemma":[0.9994942,0.0000190323,0.00009080651,0.0002381875,0.0001073172,0.00005045118],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007554834,0.00001153701,0.001558352,0.00007486727,0.00002605138,0.000002180941,0.0003656183,0.0001209455,0.98916,0.00002675042,0.00001291511,0.008565205],"study_design_scores_gemma":[0.00009292484,0.0003419243,0.01399863,0.0001458617,0.00001087846,0.00002499224,0.0006424737,0.0008860669,0.983512,0.00005594426,0.0001460593,0.0001422551],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969338,0.001056241,0.00103804,0.00003120614,0.0002655875,0.00009583048,0.00002443284,0.0000135408,0.0005412851],"genre_scores_gemma":[0.999133,0.0002574248,0.0002480959,0.00003579953,0.00006979287,0.000007213764,0.000008892255,0.00001146305,0.0002283525],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01244028,"threshold_uncertainty_score":0.5129142,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004899858456956889,"score_gpt":0.2435633886518203,"score_spread":0.2386635301948634,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}