{"id":"W4400487525","doi":"10.1016/j.psj.2024.104078","title":"Oligodeoxynucleotides containing CpG motifs upregulate bactericidal activities of heterophils and enhance immunoprotection of neonatal broiler chickens against Salmonella Typhimurium septicemia","year":2024,"lang":"en","type":"article","venue":"Poultry Science","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Prince Edward Island; University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; Chicken Farmers of Saskatchewan","keywords":"CpG Oligodeoxynucleotide; Degranulation; Phagocytosis; Respiratory burst; Innate immune system; Biology; Immune system; CpG site; Microbiology; TLR9; Salmonella; Flow cytometry; Immunity; Immunology; Bacteria; Receptor; DNA methylation; Biochemistry; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001021072,0.0003091016,0.0002072373,0.0001696302,0.00005256859,0.0001396429,0.00009230848,0.0002054086,0.0005420604],"category_scores_gemma":[0.0001039296,0.00009163011,0.0001145393,0.00004225285,0.0001307477,0.00009535479,0.00008697002,0.0003350357,0.0001417236],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001277785,"about_ca_system_score_gemma":0.0001114641,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005265742,"about_ca_topic_score_gemma":0.001202226,"domain_scores_codex":[0.9999142,0.00001377132,0.00000930386,0.00002485754,0.00001786722,0.00002005693],"domain_scores_gemma":[0.9998655,0.00002057568,0.00003950151,0.000007805349,0.00002287441,0.00004372565],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007026633,0.00001452993,0.00008935582,0.00001801478,0.000001062458,0.000006109449,0.000004413238,0.00001176303,0.9993017,0.000003788747,0.000004413883,0.0004745801],"study_design_scores_gemma":[0.00002605289,0.002059594,0.009220973,0.00001114587,0.00001986046,0.0000773776,0.00003134275,0.0005205695,0.9872436,0.00001108925,0.0007735897,0.00000480269],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979779,0.0007080465,0.0008418703,0.00002587751,0.00001925494,0.00001931978,0.00006732798,0.00002912818,0.0003113315],"genre_scores_gemma":[0.9950103,0.0006325426,0.002667597,0.00007395492,0.00001189812,0.00003985694,0.0001810539,0.00001170992,0.001371194],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005420604,"threshold_uncertainty_score":0.001813412,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004899858456956889,"score_gpt":0.2435633886518203,"score_spread":0.2386635301948634,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}