{"id":"W4400487939","doi":"10.1371/journal.pone.0304984","title":"Meaningful changes in motor function in Duchenne muscular dystrophy (DMD): A multi-center study","year":2024,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Great Ormond Street Institute of Child Health; Italfarmaco; NS Pharma; Hospital for Sick Children; Hacettepe Üniversitesi; Shire; Daiichi-Sankyo; Vertex Pharmaceuticals; Cambridge University Hospitals; University of Oxford; University College London; Sarepta Therapeutics; University Hospital Southampton NHS Foundation Trust; Ultragenyx Pharmaceutical; University of Texas at Austin; National Institutes of Health; BioMarin Pharmaceutical; University of California, Davis; Oxford University Hospitals NHS Foundation Trust; Astellas Pharma; Cincinnati Children's Hospital Medical Center; FibroGen; National Institute on Disability and Rehabilitation Research; Nationwide Children's Hospital; University of Cambridge; Children's Hospital of Philadelphia; National Institute for Health and Care Research; Universidade de São Paulo; Parent Project Muscular Dystrophy; Roche; Pfizer; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; PTC Therapeutics; Entrada Therapeutics","keywords":"Duchenne muscular dystrophy; Motor function; Muscular dystrophy; Medicine; Center (category theory); Physical medicine and rehabilitation; Internal medicine; Chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01456183,0.0006999573,0.0008889913,0.0007521004,0.0005472557,0.0008997554,0.0006818154,0.0007805582,0.0009312397],"category_scores_gemma":[0.0138236,0.0003359202,0.001163591,0.0008016275,0.0005657176,0.0007430338,0.00114899,0.0006540735,0.0001438642],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005523789,"about_ca_system_score_gemma":0.00041494,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001357364,"about_ca_topic_score_gemma":0.002072999,"domain_scores_codex":[0.9929008,0.004770698,0.000543138,0.001008641,0.0005875131,0.0001891334],"domain_scores_gemma":[0.9848132,0.006359601,0.004947787,0.001650566,0.0009792186,0.001249701],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01598809,0.0009871878,0.966937,0.000273582,0.005086099,0.0001714565,0.0003920932,0.0008454356,0.00120284,0.00008556444,0.0002893438,0.007741218],"study_design_scores_gemma":[0.0008189147,0.003963585,0.9926103,0.00002860072,0.0009949349,0.000146246,0.0001164125,0.0008214063,0.0001772414,0.00005325274,0.0002498837,0.0000191646],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984007,0.0005688332,0.0004065942,0.00003265975,0.000004777,0.00009460747,0.0003186727,0.00000601093,0.000167112],"genre_scores_gemma":[0.9990338,0.00008644761,0.0003361012,0.00002927536,0.00001404969,0.00007236951,0.0003557703,0.000002365807,0.00006992287],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01456183,"threshold_uncertainty_score":0.07701123,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02784709565019794,"score_gpt":0.2378062565803178,"score_spread":0.2099591609301198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}