{"id":"W4400490878","doi":"10.1038/s41467-024-49998-0","title":"Characterising the genetic architecture of changes in adiposity during adulthood using electronic health records","year":2024,"lang":"en","type":"article","venue":"Nature Communications","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Clarendon Fund; Engineering and Physical Sciences Research Council; Tartu Ülikool; Eesti Teadusagentuur; European Regional Development Fund; Li Ka Shing Foundation; European Commission; University of Oxford; NIHR Oxford Biomedical Research Centre; Rhodes Scholarships; Novo Nordisk; National Institute for Health and Care Research; Novo Nordisk UK Research Foundation; Wellcome Trust; Research Councils UK; Office of Research and Development; U.S. Department of Veterans Affairs; Novartis Foundation; Wellcome; Alan Turing Institute; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Bill and Melinda Gates Foundation; National Institutes of Health; University of Leicester; U.S. Department of Health and Human Services","keywords":"Genetic architecture; Body mass index; Heritability; Biobank; Obesity; Genome-wide association study; Demography; Genetic correlation; Medicine; Gerontology; Genetics; Biology; Single-nucleotide polymorphism; Genetic variation; Quantitative trait locus; Internal medicine; Genotype; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00136201,0.0002169005,0.000285015,0.001532827,0.0003211789,0.000769942,0.0004908284,0.000401819,0.001066631],"category_scores_gemma":[0.007056819,0.0002422728,0.0004115128,0.003255148,0.0002294406,0.0004925477,0.0007266166,0.0004228568,0.0003095286],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003102219,"about_ca_system_score_gemma":0.0003637444,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0178579,"about_ca_topic_score_gemma":0.02424897,"domain_scores_codex":[0.9982669,0.0004161357,0.0002664308,0.0005520937,0.0003516279,0.0001466624],"domain_scores_gemma":[0.9953497,0.001107417,0.002204091,0.0007388036,0.0004389138,0.0001610898],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00005929438,0.00001688424,0.9960425,0.00001786679,0.0001229617,0.00006157847,0.0001273349,0.0001320146,0.000431122,0.00008973486,0.0002234925,0.002675285],"study_design_scores_gemma":[0.000004065769,0.0000205201,0.9990183,0.00001023055,0.00003079525,0.00008537056,0.00006142153,0.0003450704,0.000110226,0.00005950909,0.0002510676,0.000003401366],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994396,0.0002121086,0.001029833,0.0001015909,0.000004551258,0.0000198482,0.003707984,0.0000168939,0.0005112583],"genre_scores_gemma":[0.9937294,0.0002280163,0.0013888,0.00004429794,0.00001090308,0.00003183658,0.004259055,0.000007638244,0.0003000808],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0178579,"threshold_uncertainty_score":0.03550792,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01395882555503955,"score_gpt":0.3105446836213512,"score_spread":0.2965858580663117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}