{"id":"W4400498014","doi":"10.1038/s41467-024-49595-1","title":"Immuno-oncologic profiling of pediatric brain tumors reveals major clinical significance of the tumor immune microenvironment","year":2024,"lang":"en","type":"article","venue":"Nature Communications","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Alberta; University of Toronto; SickKids Foundation; Hospital for Sick Children; University of British Columbia","funders":"CIHR Skin Research Training Centre; Stand Up To Cancer; Government of Canada; Canadian Institutes of Health Research; Ontario Genomics; Genome Canada; Hospital for Sick Children; Garron Family Cancer Centre; Bristol-Myers Squibb","keywords":"Tumor microenvironment; Immune system; Brain tumor; Medicine; Cancer research; Biology; Pathology; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002584727,0.0001937074,0.0002186599,0.0008752879,0.0001320703,0.0003837419,0.0001097773,0.0001899085,0.0006965867],"category_scores_gemma":[0.0004983489,0.00009074406,0.0001147353,0.0006172286,0.0002459365,0.0001762025,0.0002256311,0.0002976748,0.0002503404],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002086723,"about_ca_system_score_gemma":0.0001925265,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005632159,"about_ca_topic_score_gemma":0.001255244,"domain_scores_codex":[0.9997831,0.0000336968,0.00001725474,0.00005855969,0.00006083841,0.00004662357],"domain_scores_gemma":[0.9996603,0.00007351003,0.0001462241,0.0000223261,0.00005141634,0.00004634053],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007016346,0.00004728053,0.4642837,0.0001169446,0.00004474006,0.000609181,0.000244332,0.0007983163,0.5057169,0.0002741151,0.0003036895,0.02685931],"study_design_scores_gemma":[0.000007978037,0.0003916711,0.8450683,0.00001631289,0.00005620248,0.003682792,0.0004040739,0.00153816,0.1446777,0.0003013696,0.003843931,0.00001139372],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948814,0.0007154467,0.002682341,0.00004425216,0.000003934077,0.00001943395,0.0008073419,0.00003414755,0.0008117552],"genre_scores_gemma":[0.9946795,0.0006895842,0.003254526,0.00003531949,0.000006832358,0.00003367752,0.0009138038,0.00002012647,0.0003665703],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008752879,"threshold_uncertainty_score":0.002330363,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02880327993577449,"score_gpt":0.3461658010259828,"score_spread":0.3173625210902083,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}