{"id":"W4400513145","doi":"10.21203/rs.3.rs-4559920/v1","title":"The Retrotransposon-Derived Capsid Genes PNMA1 and PNMA4 Maintain Reproductive Capacity","year":2024,"lang":"en","type":"preprint","venue":"Research Square","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; Irving Medical Center, Columbia University; National Institute of Food and Agriculture; National Institutes of Health; Buck Institute for Research on Aging; Echo Foundation; Wellcome Trust; Montana State University; M.J. Murdock Charitable Trust; U.S. Department of Agriculture","keywords":"Retrotransposon; Biology; Gene; Capsid; Genome; Offspring; Genetics; Mutant; Domestication","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000229203,0.0006077886,0.0004262737,0.0004646261,0.0004872736,0.001182441,0.0006738767,0.0007397044,0.006895513],"category_scores_gemma":[0.0007021025,0.0003341798,0.0004010717,0.0002886681,0.0007587488,0.0007881949,0.0009535081,0.001605404,0.003681602],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007253838,"about_ca_system_score_gemma":0.0006654984,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007972118,"about_ca_topic_score_gemma":0.0009310055,"domain_scores_codex":[0.9997328,0.00002493344,0.000009052169,0.00007077222,0.00009576249,0.00006663117],"domain_scores_gemma":[0.999501,0.0001101282,0.00008628027,0.0001490332,0.00005697814,0.00009657228],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000679068,0.0000122484,0.0004628588,0.00003169107,0.000005835897,0.00008710754,0.00003724625,0.0003110001,0.988356,0.00384534,0.0003052857,0.006477523],"study_design_scores_gemma":[0.00001960459,0.00005879911,0.003662828,0.000009516721,0.00001216586,0.0004730911,0.00005047459,0.003174645,0.9719581,0.003633377,0.0169254,0.00002203527],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8590787,0.001060895,0.09634168,0.0005469332,0.000387617,0.00008272241,0.002235322,0.003615175,0.03665085],"genre_scores_gemma":[0.9372557,0.0003637244,0.0189024,0.00009324269,0.00003825629,0.00004637287,0.002128671,0.001213314,0.03995838],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006895513,"threshold_uncertainty_score":0.02306777,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03267467060534194,"score_gpt":0.3797483501532213,"score_spread":0.3470736795478793,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}