{"id":"W4400514580","doi":"10.1101/2024.07.09.602712","title":"Transcription Factors DksA and PsrA are synergistic contributors to <i>L. pneumophila</i> virulence in <i>Acanthamoeba castellanii</i> protozoa","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Legionella and Acanthamoeba research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Protozoa; Virulence; Microbiology; Biology; Transcription (linguistics); Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001480914,0.0006814071,0.0003854642,0.0002696791,0.0002216851,0.000520305,0.0002783734,0.0003323155,0.0009722349],"category_scores_gemma":[0.0001649879,0.0003547247,0.0003981844,0.0001276251,0.0004690436,0.0002253588,0.0005750119,0.0006363422,0.0005297016],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005326361,"about_ca_system_score_gemma":0.0004664426,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001293586,"about_ca_topic_score_gemma":0.002472473,"domain_scores_codex":[0.9996189,0.00004850261,0.00003807478,0.00009413934,0.0001229675,0.00007730888],"domain_scores_gemma":[0.999754,0.00002572708,0.00008119287,0.00003108983,0.00002200352,0.00008597884],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006923071,0.000008578429,0.0004992961,0.0000292593,0.000004128988,0.00006186082,0.000009936565,0.00004781716,0.9988048,0.00005104139,0.00001848949,0.0003956251],"study_design_scores_gemma":[0.00001213511,0.0001107873,0.01125211,0.00001018091,0.00003582455,0.0005057825,0.0000820209,0.001511877,0.9838643,0.00007714598,0.002524951,0.00001303839],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931893,0.001932259,0.002853747,0.0001453089,0.00003103026,0.00001268049,0.0002714328,0.0002207066,0.001343447],"genre_scores_gemma":[0.9969633,0.0003213719,0.001416004,0.00006073026,0.000006434892,0.000008603113,0.0002673534,0.0000299402,0.0009262392],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001293586,"threshold_uncertainty_score":0.003864586,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01294938334679373,"score_gpt":0.2355079113356062,"score_spread":0.2225585279888125,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}