{"id":"W4400522536","doi":"10.1002/cbic.202400443","title":"Genome Mining Leads to the Identification of a Stable and Promiscuous Baeyer‐Villiger Monooxygenase from a Thermophilic Microorganism","year":2024,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Enzyme Catalysis and Immobilization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Thermophile; Identification (biology); Microorganism; Genome; Monooxygenase; Computational biology; Biology; Genetics; Biochemical engineering; Biotechnology; Gene; Biochemistry; Enzyme; Bacteria; Ecology; Cytochrome P450; Engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002282251,0.0005516588,0.0005937611,0.001043075,0.0003213845,0.000779969,0.0002806834,0.0005498986,0.0006569886],"category_scores_gemma":[0.0007378493,0.0002009444,0.0007532524,0.001589941,0.0001661596,0.0004166297,0.000434495,0.0006269995,0.0004947895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003437092,"about_ca_system_score_gemma":0.00042446,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00135347,"about_ca_topic_score_gemma":0.002072194,"domain_scores_codex":[0.9997965,0.00001938951,0.00001710614,0.00008620557,0.00005200014,0.00002883282],"domain_scores_gemma":[0.9997768,0.00005476276,0.00008047217,0.00001878206,0.00003946611,0.00002976173],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005483081,0.0001567054,0.0183998,0.0006424962,0.000128523,0.0009424118,0.0002427586,0.001397731,0.9243987,0.0005004292,0.000598956,0.05204318],"study_design_scores_gemma":[0.00009936139,0.001554074,0.2624892,0.0004183806,0.001090632,0.007988072,0.001831676,0.03485862,0.6279587,0.003208975,0.05834934,0.0001530135],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9560823,0.003708588,0.02751502,0.0003882412,0.00002982467,0.0001271849,0.009631991,0.0004711432,0.002045574],"genre_scores_gemma":[0.8934447,0.003123671,0.06827956,0.0001756134,0.00001882819,0.00009569734,0.03274054,0.0001666863,0.00195461],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00135347,"threshold_uncertainty_score":0.00269115,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007470859020300674,"score_gpt":0.2243776692766964,"score_spread":0.2169068102563958,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}