{"id":"W4400525702","doi":"10.1152/ajprenal.00117.2024","title":"Paradoxes in magnesium transport in type 1 Bartter’s syndrome and Gitelman’s syndrome: a modeling analysis","year":2024,"lang":"en","type":"article","venue":"American Journal of Physiology-Renal Physiology","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Bartter syndrome; Hypocalciuria; Gitelman syndrome; Endocrinology; Internal medicine; Transporter; Cotransporter; Chemistry; Nephron; Hypokalemia; Kidney; Medicine; Magnesium; Sodium; Hypomagnesemia; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002374384,0.0002369895,0.0007085132,0.0005825314,0.00002737413,0.000008100459,0.0001855084,0.0001366561,0.00003404306],"category_scores_gemma":[0.000007350808,0.0002029974,0.0002358596,0.0008278051,0.0002732195,0.00002328103,0.00002539613,0.0002907542,0.000003245975],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000233244,"about_ca_system_score_gemma":0.00009669465,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001000386,"about_ca_topic_score_gemma":0.0001055684,"domain_scores_codex":[0.9983843,0.0001339927,0.0006029794,0.0004291429,0.0001120583,0.0003375073],"domain_scores_gemma":[0.9994696,0.00002755925,0.0001630346,0.0001814679,0.00007073894,0.00008762022],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006990931,0.0001026371,0.00413579,0.00006990788,0.0004223179,0.0001814562,0.0002228999,0.05354923,0.939517,0.00003236284,0.00001447865,0.001052852],"study_design_scores_gemma":[0.001044013,0.003666666,0.9696349,0.0001419527,0.0004759325,0.0008365729,0.0004328054,0.0175106,0.00346397,0.001971841,0.0002298474,0.0005909087],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977046,0.001411306,0.0004143135,0.0001805274,0.0001807864,0.00007947398,0.00001028015,0.000007690802,0.0000110793],"genre_scores_gemma":[0.9989851,0.0004359806,0.0001728604,0.0001340688,0.000115945,0.000006835277,0.0001035154,0.00002291555,0.00002285264],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9654991,"threshold_uncertainty_score":0.8277993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006589422474551312,"score_gpt":0.2333723440492202,"score_spread":0.2267829215746689,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}