{"id":"W4400525702","doi":"10.1152/ajprenal.00117.2024","title":"Paradoxes in magnesium transport in type 1 Bartter’s syndrome and Gitelman’s syndrome: a modeling analysis","year":2024,"lang":"en","type":"article","venue":"American Journal of Physiology-Renal Physiology","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Bartter syndrome; Hypocalciuria; Gitelman syndrome; Endocrinology; Internal medicine; Transporter; Cotransporter; Chemistry; Nephron; Hypokalemia; Kidney; Medicine; Magnesium; Sodium; Hypomagnesemia; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003043732,0.0004929667,0.0009558498,0.0005251407,0.0005722372,0.0008108098,0.001085489,0.001688184,0.002243395],"category_scores_gemma":[0.001272693,0.0003647361,0.001141625,0.0004489173,0.0006078216,0.0006089154,0.000688078,0.0005512793,0.0001472665],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001163009,"about_ca_system_score_gemma":0.001684313,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0301494,"about_ca_topic_score_gemma":0.01573557,"domain_scores_codex":[0.9998953,0.00003862645,0.000004911636,0.00001716156,0.00001471763,0.00002935316],"domain_scores_gemma":[0.9993879,0.0003926921,0.00006759526,0.00002539875,0.00006455381,0.00006192499],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00007015187,0.00004377354,0.002464833,0.00003215467,0.00004103266,0.0001953566,0.00005097718,0.988804,0.0007078901,0.006387328,0.0004572425,0.0007452776],"study_design_scores_gemma":[0.00002832434,0.00001321615,0.0005612649,0.000004677357,0.00001369572,0.00001929514,0.00003176374,0.9971946,0.00006521326,0.001833853,0.0002269393,0.00000711945],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9638739,0.0005341229,0.01683448,0.001790276,0.00007594244,0.00004099773,0.000852738,0.0001232276,0.01587432],"genre_scores_gemma":[0.9932088,0.0002840448,0.003343348,0.0001817698,0.00002163552,0.00007311263,0.0002323914,0.00003457597,0.00262024],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0301494,"threshold_uncertainty_score":0.05994785,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006589422474551312,"score_gpt":0.2333723440492202,"score_spread":0.2267829215746689,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}